If by "this" you mean the affair with Powell, probably not much difference between Jensen Huang's affair with Powell and affairs that Gates, Bezos, and Brin have reportedly had.

But the extramarital affair with Alice Huang is quite different. NYTimes reports that Alice Huang is a Chinese spy, with whom Jensen Huang may have conspired to break the law, selling advanced NVIDIA chips to China. That affair puts the whole company at extreme legal risk. Gates, Bezos, and Brin have nothing like this on their records that I'm aware of.

As I write this, the top post on HN speculates that this is "the tip of the iceberg," indicating that there at least may be more affairs yet to be uncovered, and, plausibly, Jensen Huang may have committed even more enormous mistakes with serious consequences for NVIDIA.