Yes, I remember trying to set up Omnisphere and it just wouldn't work for me. So my issues were related to windows VST's. I used Wine and yabridge, which did install them but they weren't usable.

Was that some time ago? I find Yabridge to work reliably on numerous plugins.

It was last year and then I tried again some weeks ago. The issues I had were sometimes crackling audio and not being able to close a plugin's GUI window.