Ozempic-style drugs now in trials for heart failure, addiction and even aging

Re:Ozempic-style drugs now in trials for heart failure, addi... by traviswingo on Saturday November 07, 2026 @10:47AM (#50405523)

I personally don’t think it’s that complicated. I think it’s simply just the result of caloric density increasing as foods become engineered to make us want more. They’re saltier, sweeter, and generally more addictive. You can eat 2,000 calories in a sitting and not “feel full.”

Now, if you remove breads, sugars, and processed foods, try eating the same number of calories with whole foods only. You’ll become full way before you reach that number.

And some people, like your wife, simply respond to food differently. Id say she’s in the minority, though.

I, like yourself and most people, don’t feel full until I’ve eaten an unreasonable amount of certain types of foods. Since switching to Whole Foods and cutting out breads, sugars, and processed foods, I’ve lost weight while eating until I’m full/satisfied.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by rubicon33 on Saturday November 07, 2026 @12:45PM (#50406436)

Stomach size is probably a massively under appreciated factor. If you naturally have a smaller build, you’ll likely have a smaller stomach, and that sense of being full will arrive much sooner.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by tstrimple on Saturday November 07, 2026 @08:08PM (#50409609)

Based on my experience fasting (as a huge guy) stomach size fluctuates quite a bit and is mostly conditioned on your eating habits. There have been times in my life where I could finish off a large pizza myself. These days I feel stuffed after one or two slices and a breadstick regardless of how little I’ve eaten during the day. Days I eat less I find I can eat less later. If I have breakfast (usually only ever on vacation) I can eat more later in the day before feeling full.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by rubicon33 on Monday November 09, 2026 @12:51PM (#50428905)

I agree there's a range but - arm chair doctor here - believe that a bigger abdominal cavity leaves more room for that expansion, so bigger people are able to expand their stomach to a larger size before pain and discomfort.

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