Ozempic-style drugs now in trials for heart failure, addiction and even aging

Re:Ozempic-style drugs now in trials for heart failure, addi... by arjie on Friday November 06, 2026 @04:40PM (#50398878)

These drugs are a godsend for so many (me included, on retatrutide) but especially for those of us here in America - legal environment broad enough to get them, relatively wealthy enough to afford them, and notably fat enough to benefit from them. The diffusion of this technology through the US might well increase American lifespan in a notable way.

Now all we need is an easy pill that makes you hate opioids.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by solyin on Friday November 06, 2026 @09:44PM (#50401124)

Supposedly narcan does that. Instead of after an overdose, if you have narcan administered beforehand, opioids are no fun.

Not about to try and get some first hand experience with that tho!

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Re:Ozempic-style drugs now in trials for heart failure, addi... by ulrikrasmussen on Saturday November 07, 2026 @12:15AM (#50401842)

No, it blocks the effects of opioids, but it doesn't remove the cravings or withdrawal

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Re:Ozempic-style drugs now in trials for heart failure, addi... by MisterMunchkin on Saturday November 07, 2026 @05:47AM (#50403379)

And it only lasts minutes.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by randycupertino on Friday November 06, 2026 @10:33PM (#50401385)

How are you getting retatrutide? Are you in a trial? How is it working for you?

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Re:Ozempic-style drugs now in trials for heart failure, addi... by thechao on Friday November 06, 2026 @11:12PM (#50401535)

Small peptide suppliers make them. You order by generic identifier & compound yourself. My identical twin & I are running an exponent: I'm on foundayo, he's on retatrutide. I'm down about 10 lbs. he's down 35.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by hashmap on Saturday November 07, 2026 @08:26AM (#50404380)

Real gamble, that. You're injecting something that no regulatory body that said was safe and that that supplier is giving you what they say they are? Just like injecting whatever it is they happen to give you?

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Re:Ozempic-style drugs now in trials for heart failure, addi... by phil21 on Saturday November 07, 2026 @09:43AM (#50404973)

If you're doing this sort of thing, usually you batch your orders together (ideally with some friends) and randomly lab test a few vials selected from the large batch you receive. The powder form vials you receive before mixing will last more or less indefinitely in a freezer, so you can order multiple years worth of supply at a time.

The potency and purity are typically pretty good, but from time to time vendors will be outed for either outright fraud or a bad batch that is underfilled or whatnot. Most of the direct vendors (out of China) will guarantee fill and purity, and also give credit on your next order for lab test costs if you share the tests with them for future marketing purposes.

All sorts of risks involved of course, but you can mitigate them fairly effectively. Your risk tolerance may vary. Some folks will buy single vials from US resellers and trust those seller's lab test reports. Others (smartly, imo) don't trust that and do their own testing directly on the product they receive.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by estearum on Saturday November 07, 2026 @10:31AM (#50405380)

Profoundly stupid shit.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by JumpCrisscross on Saturday November 07, 2026 @12:05PM (#50406100)

Risky. Not necessarily stupid. I wouldn’t do it. But we’d have to observe the injury rate before being able to conclude anything.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by estearum on Sunday November 08, 2026 @01:00PM (#50415515)

No, you can know that decisions are stupid before knowing their outcome. In fact, decisions can be stupid even when they result in a neutral or positive outcome.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by estearum on Saturday November 07, 2026 @10:30AM (#50405376)

What's the experiment?

"Person A takes Foundayo, Person B takes mystery drug?"

Not sure what you think you're learning from that.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by thechao on Saturday November 07, 2026 @12:08PM (#50406130)

Are you asking if we're learning about the general population, or about ourselves? We're 100% identical twins with nearly identical blood work across a fairly deep blood panel. We're learning precisely what we need to know to maximize efficacy for us.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by estearum on Sunday November 08, 2026 @01:00PM (#50415511)

I'm saying that the "retatrutide" test subject has no way to access known-good retatrutide.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by MisterMunchkin on Saturday November 07, 2026 @05:54AM (#50403416)

There is an injection for opiods that works for a month at a time. It really annoys me because we’re still giving people methadone every day even though this injection exists.

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Re:Ozempic-style drugs now in trials for heart failure, addi... by JKCalhoun on Saturday November 07, 2026 @09:52AM (#50405055)

Zepbound has been a godsend for me—trying unsuccessfully to lose weight for two decades now…

One weird aspect of it working as well as it has on me is that when I see people who are morbidly obese in public now I have to fight the urge to proselytize GLP-1.

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