Nah, dragon sword is the best once you push manual combat to the maximum level. Takes out pretty much everyone in one hit. I played through the game dozens of times and it's my standard pick for 99% of playthrough. Just need a little extra for the bots.

Fully upgraded pistol was stupidly powerful. Only reason I wouldnt do it again was I kept running out of ammo. But if I found 1 bullet, that would be 1 kill guaranteed.