Early-life stress leaves a 'scar' inside brain cells

Re:Early-life stress leaves a 'scar' inside brain cells by Noaidi on Saturday August 22, 2026 @10:34AM (#49400187)

Not a scar IMHO, but a wound that can be healed. SETD7 is a Histone Methyltransferase. Meaning it attaches methyl groups to DNA which turns genes off. But there are enzymes that remove these methyl groups as well and they are called Demethylases [1]. Many of these enzymes can be stimulated by their nutritional cofactors which are things like Zinc, Iron, and Riboflavin.

I am a product of early life trauma. Knowing these thing have helped me tremendously.

[1] https://www.uniprot.org/uniprotkb/Q8NB78/entry

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Re:Early-life stress leaves a 'scar' inside brain cells by diydsp on Saturday August 22, 2026 @01:04PM (#49401583)

Wait that's very interesting. Any suggs for bio hacking?

Iiuc zinc can be tricky/fraught to experiment with and iron somewhat risky. Don't know about B2.

So perhaps start with each one on small dose, one week one, two weeks off, keep a journal, making no other changes?

And any suggs for things to avoid?

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Re:Early-life stress leaves a 'scar' inside brain cells by Noaidi on Saturday August 22, 2026 @01:09PM (#49401622)

I would never suggest anything. We each have our own genetic/environmental needs. But you can get tested for many of these nutrients to see if you have a deficiency.

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Re:Early-life stress leaves a 'scar' inside brain cells by madaxe_again on Saturday August 22, 2026 @01:26PM (#49401762)

I find enough weed to sink a battleship also works.

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