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Re:The first early human eggs from stem cells by rf15 on Wednesday July 01, 2026 @02:37AM (#48743062)
genuinely curious: how does any life still exist if this holds true?
Re:The first early human eggs from stem cells by scotty79 on Wednesday July 01, 2026 @02:48AM (#48743115)
When the damage accumulates across generations the natural selection has opportunity to weed out particularly harmful instances. You can get a feeling for how important avoiding the mitochondrial damage is and how hard it is to mitigate, by looking at how fiercely the reproductive process protects them from aging.
Re:The first early human eggs from stem cells by someonebaggy on Wednesday July 01, 2026 @05:12AM (#48744163)
And with this you get a hundred times the damage (mutation) but still only the same amount of selection.
Re:The first early human eggs from stem cells by jmcgough on Wednesday July 01, 2026 @04:29AM (#48743789)
I think they're arguing that a somatic cell from an older human contains mitochondria that's more degraded. Egg cells are all created before birth, and each is pre-seeded with a large number of mitochondria.