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A comment on Vitamin D and Omega-3 have a larger effect on depression than antidepressants. Parent comment

Re:Vitamin D and Omega-3 have a larger effect on depression ... by Noaidi on Thursday January 29, 2026 @11:46AM (#46812656)
Yes. Made me manic. You know we make niacin in our own bodies, from tryptophan, down the kynurenine pathway. Sine many of the enzymes that are in this pathway need B6 and B2, being low in these may lower endogenous niacin in the body.

https://www.researchgate.net/publication/353319033/figure/fi...

Many people I know, when tested, were low in B6. That is more important to me than niacin.

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Re:Vitamin D and Omega-3 have a larger effect on depression ... by ulnarkressty on Thursday January 29, 2026 @03:12PM (#46815908)
For others who want to try this, taking too much B6 is associated with nerve damage - https://en.wikipedia.org/wiki/Megavitamin-B6_syndrome
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Re:Vitamin D and Omega-3 have a larger effect on depression ... by lII1lIlI11ll on Thursday January 29, 2026 @05:21PM (#46817615)
From your link: "The common supplemental form of vitamin B6, pyridoxine, is similar to pyridine, which can be neurotoxic."

Vitamin B6 in p5p form is cheap and widely available alternative.

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