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Re:California to begin selling affordable state-branded insu... by JumpCrisscross on Thursday October 16, 2025 @06:00PM (#45611210)
> bill that would have set a $35 cap for insulin

Because this worked so well for home insurance.

$35 in 2025 dollars buys as much as $32.92 in 2023 dollars [1]. At what point does it become unprofitable for anyone to manufacture and deliver? (Not the out-of-patent stuff nobody wants to take that can be made for $3/vial. The long-acting and ultra-fast formulations people actually use when given a choice.)

And unlike with home insurance, in an insulin shortage, people die. You need a CalFIRE mechanism, a seller of last resort, who will purchase the insulin at any price on the market and sell it at $35 for such a scheme to work.

State-controlled production removes that surprise factor. It's a much better system than price regulation.

[1] https://www.usinflationcalculator.com

Re:California to begin selling affordable state-branded insu... by hodgehog11 on Thursday October 16, 2025 @06:13PM (#45611320)
The difference is that the proposed caps for home insurance would have made the product unprofitable, no question.

My understanding is that there is no way any vial of insulin anywhere, at this point in time, should cost enough to produce for US$35 asking price to be unprofitable. See [1] and [2] for example. This would need to increase with inflation, of course.

Regardless, the bill didn't pass. Arguments like this were probably the reason why.

[1] https://www.mayoclinicproceedings.org/article/S0025-6196(21)... [2] https://www.medcentral.com/endocrinology/diabetes/the-high-c...

Re:California to begin selling affordable state-branded insu... by dragonwriter on Friday October 17, 2025 @01:00AM (#45613433)
> My understanding is that there is no way any vial of insulin anywhere, at this point in time, should cost enough to produce for US$35 asking price to be unprofitable.

The vetoed bill (SB 90 of 2023) did not address the price of insulin, only the allowable insurance copay for insulin. The fact that this, without addressing the actual price, would just shift the costs from copays to premiums was called out in the veto message.

Also note that, with CalRx's insulin initiative ready to deliver at the same time the bill goes into effect, SB 40 of 2025 which set the same copay cap as SB 90 of 2023, was signed by Newsom this week.

Re:California to begin selling affordable state-branded insu... by Teever on Thursday October 16, 2025 @07:26PM (#45611892)
What if the price cap was set at whatever Canadians pay for insulin?

It seems like insulin is a lot more affordable there and it's obviously an economically sustainable rate because companies keep selling it to Canada.

How much does it cost in Canada anyways?

Re:California to begin selling affordable state-branded insu... by TimBurman on Friday October 17, 2025 @01:18PM (#45619262)
Fast Acting Humalog 1000 unit (10 ml) vials cost CAD $40.34 = USD $28.73 in Alberta. Anyone can get Blue Cross from the government which is CAD $720 a year. Then each 3 month supply of a prescription like insulin has a co-pay of $28 a quarter, for however many vials you need. I last used Lantus 24 hour insulin in 2020, when it was around CAD $60, but the government has been switching to biosimilar brands and providing free insulin pumps and supplies including test strips, which only use fast acting insulins. Lantus is most similar to this California insulin.
Re:California to begin selling affordable state-branded insu... by jrflowers on Thursday October 16, 2025 @06:53PM (#45611662)
> The long-acting and ultra-fast formulations people actually use when given a choice.

The patent for insulin glargine (Lantus) and insulin aspart (NovoLog) expired over a decade ago, though kind of amusingly Sanofi holds an active patent on “putting more Lantus in a vial than you usually would”

https://patents.google.com/patent/US9345750B2/en

I could be wrong but off the top of my head the only insulin I can think of that’s probably under patent is Afrezza, which is cool as hell because it’s inhalable and ultra-quick

Re:California to begin selling affordable state-branded insu... by JumpCrisscross on Thursday October 16, 2025 @07:08PM (#45611756)
It’s less the patent per se than the production cost. A lot of cost estimates use the 1980s Humalin or whatnot as their baseline. I’m not diabetic. But everyone I know who is doesn’t like that one. So we need to know the cost for the medicines folks are actually taking.
Re:California to begin selling affordable state-branded insu... by jrflowers on Thursday October 16, 2025 @07:42PM (#45611991)
It looks like the cost to manufacture modern biosimilars could be around $2-6 per vial.

https://gh.bmj.com/content/3/5/e000850

Re:California to begin selling affordable state-branded insu... by s1artibartfast on Friday October 17, 2025 @11:37AM (#45618001)
Cost to manufacture obviously isnt the only factor.
Re:California to begin selling affordable state-branded insu... by dragonwriter on Friday October 17, 2025 @12:57AM (#45613423)
It's worth noting that the veto message on the 2023 bill (which did not cap insulin prices, but only insurance copays for insulin) explicitly called out the CalRx project as providing the real solution, and noted that capping copays without addressing actual drug costs would result in the actual price just getting passed on to consumers via insurance premiums.

It is also worth noting that this week Newsom signed SB 40 0f 2025, which did exactly the same thing in this area as the vetoed SB 90 of 2023, no doubt because the price side was also being adddressed simultaneously, with CalRx insulin to be on available in January when SB 40 goes into effect.