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Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by fortran77 on Wednesday August 06, 2025 @12:37AM (#44807689)
I think that, just like with stomach reduction surgery, people are going to find a way to overeat and gain weight while taking Ozempic too.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by glp1guide on Wednesday August 06, 2025 @12:49AM (#44807747)
Nope, because the change is actually in the brain.

https://glp1.guide/content/research-on-glp1-signaling-in-the...

https://glp1.guide/content/research-suggesting-glp1-is-a-bra...

https://glp1.guide/content/are-glp1s-primarily-brain-drugs/

This is the killer feature of Semaglutide and GLP1 Receptor Agonists widely. They were originally commonly thought about as digestion-slowing, and while that is part of it, the real change is that it's a brain drug.

Oh also, on whether people gain back the weight:

https://glp1.guide/content/do-people-regain-all-the-weight-l...

tl;dr - most people (i.e. over 50%) do not.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by redwood on Wednesday August 06, 2025 @06:20AM (#44810143)
Is glp1guide a neutral source? Honest question
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by loeg on Wednesday August 06, 2025 @12:50AM (#44807754)
Uh, so, first, I'll say that bariatric surgery is largely a successful (if extremely invasive) intervention. It is not the case that people who do that surgery somehow compensate eat back to the same level -- on average, they don't. And second, the GLP-1s just massively reduce the urge to snack/eat. I'm sure they are less effective for some people than others, but on the whole they are miraculously effective for the population that overate habitually (the obese).
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by astura on Wednesday August 06, 2025 @02:16PM (#44815628)
Ozempic alters the rewards system, so if it's working you don't want to overeat, not just that you physically can't.