Is this adjusted by amount of use? As in, is it possible that it's more likely to trigger latent mental illness with alcohol and cannabis not because they trigger it more effectively, but because they are significantly more widely available, significantly more widely used, and people who consume them consume them in significantly greater amounts?

If you get drunk once, I get high once, and our friend trips on psilocybin once, what is the comparative risk of activating latent mental illness for these events alone?

I had to quit drinking, because I couldn't moderate my intake. I struggle with cannabis craving and use.

I have taken a number of psychedelic drugs, but never due to craving, and not more than a handful of times. I have had profound and life changing experiences (for the better), it's not always fun.

For what it's worth, I'm pretty sure regular use of psychedelics is not a great idea. These substances can be hard on the body and brain. Respectful and intentional use can have benefits far beyond the risk. Indeed, I may be alive today as a result of my use.

Single dose use is more likely to be harmful with ethanol at a comparable degree of intoxication, it is strongly disinhibitory in comparison, but a particular person might be more sensitive one way or the other.

We hope to push most the bad stuff beyond or as far towards death as possible, and death as far away as possible so long as not too much bad stuff is already happening. The question then becomes at what rate slow the delay of schizo-affective disorder or some other mental illness. It's coming for all of us, given enough time.