Some drugs increase heart rate dramatically - the older you are the more susceptible to atherosclerosis or other circulatory diseases. There’s more medical risk the older you are for sure. However, you may find you only need a little bit. Some drugs are funny. Some work on first try, other takes a couple tries before your brain understands the chemical.
If you're a US male, average life expectancy ~76 years, then hurting/killing yourself in your 20s you lose ~50 years of life. Hurting/killing yourself in your 70s, you lose an order of magnitude less.
I hope to remember this in my 70s! Seeing most people don't, so not having particularly high hopes...
Having a mini stroke at 26 like I did, I was able to bounce back. Having a mini stroke at 81 like my father did, resulted in his death.
Would it make a difference if it was a 70 year old who is still open minded and curious about life, the universe, and everything? (given that I'd guess that any 70+ year old willing to do LSD is likely to be as per this description).
Legitimately interested in your answer / reasoning (mainly because my plan was to experience a number of different drugs once the rest of my life, that could have been put at risk by drugs, is kinda setup and done well enough).