Ketamine implies Musk which implies DOGE.

It’s a play on the rumours that Musk abuses his ketamine prescription. Note that I’m not advocating for the rumours. Merely explaining.

The person driving the destruction of the government services in the USA is apparently self identified as a heavy ketamine user.

I think they mean vastly reduced in size and scope by DOGE, since Mr Musk is apparently doing all of his government work in a state of ketamine induced mania.

There were some other guys that famously got a lot done on stimulants.

Yes, many people have and do take various drugs, though ketamine is a dissociatieve rather than a stimulant.

Musk takes so much ketamine that his mental abilities are clearly impaired, let alone his physical health(long term k use has a bunch of serious health issues).

Elon's ketamine abuse is well documented. He's also boasted about taking it.