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A comment on Magnesium Self-Experiments. Parent comment

Re:Magnesium Self-Experiments by manmal on Sunday March 09, 2025 @05:06AM (#43307461)
Maybe you mean B6, which is associated with small fiber neuropathy.

B12 has to jump through a number of hoops before it‘s even converted into a usable form [1].

I‘m sure you‘re meaning well, but B12 deficiency is a wide spread problem [2], and it’s questionable that excess is worse than deficiency.

1: https://pubmed.ncbi.nlm.nih.gov/19832808/#&gid=article-figur...

2: https://pmc.ncbi.nlm.nih.gov/articles/PMC7792587/

EDIT: After posting, I saw your other comments. Maybe you can update parent.

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Re:Magnesium Self-Experiments by Jarmsy on Sunday March 09, 2025 @05:57PM (#43314322)
And one reason for taking B12 is actually to prevent neuropathy.
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Re:Magnesium Self-Experiments by manmal on Monday March 10, 2025 @05:18AM (#43318408)
Looking at the interactions in metabolism, I don’t see it.

A low B6 diet and focus on conversion to P5P and oxidation of the excess (Aldehyde Oxidase, and maybe by proxy the ALDHs) is a safer bet.

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