Weight-loss drug found to shrink heart muscle in mice, human cells

Re:Weight-loss drug found to shrink heart muscle in mice, hu... by cm2187 on Wednesday November 20, 2024 @07:22PM (#42199677)

You don't lose taste, you lose your appetite, which means you can resist the temptation to eat easily, and you feel full very quickly. That doesn't prevent you from eating what you like, but it does help you to not eat too much of it, which I hope is not what you mean by "more freely".

The appetite comes back when you cut the meds, but it's an appetite based on your new weight. But if you then go on a some suggar rampage, you will regain weight and your appetite will grow too.

Those drugs are merely a guard rail to complete a diet successfully, but if people do not change their eating habbits, the same causes will produce the same effects after they cut the meds.

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Re:Weight-loss drug found to shrink heart muscle in mice, hu... by andy_ppp on Wednesday November 20, 2024 @07:39PM (#42199796)

What I’ve found is foods I could usually binge on like pizza I’m quite full on GLP-1 inhibitors and can quite happily stop at half or 2/3 of a pizza. Usually I’d have eaten the whole thing (12” think napoleon style pizza Americans) and want more, refined carbs I never feel full from.

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Re:Weight-loss drug found to shrink heart muscle in mice, hu... by hnthrowaway0328 on Wednesday November 20, 2024 @07:28PM (#42199716)

Thanks, that's good enough. I have been going to weight loss for over 6 months but I'm stuck between 79 and 80kg. It's a bit difficult to add more weight lifting because I tended to hurt myself, so eat less is better.

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Re:Weight-loss drug found to shrink heart muscle in mice, hu... by andy_ppp on Wednesday November 20, 2024 @07:40PM (#42199807)

Add walking for 2h per day is the recommended I’ve seen.

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Re:Weight-loss drug found to shrink heart muscle in mice, hu... by hnthrowaway0328 on Wednesday November 20, 2024 @09:19PM (#42200416)

Thanks, 2h is a bit too much for me, so what I do is about 3-4 10-12 mins walk-sprint walk reps. Basically half walk (3.5m/h) and half sprint-walk (4.4m/h). I wish I could do more but my joints are not really good.

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Re:Weight-loss drug found to shrink heart muscle in mice, hu... by theendisney on Wednesday November 20, 2024 @09:56PM (#42200645)

Just walking is better. You get a steady burn. If you do high intensity you burn calories for a good while afterwards. Mild intensity doesnt do much.

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Re:Weight-loss drug found to shrink heart muscle in mice, hu... by throwaway2037 on Wednesday November 20, 2024 @08:32PM (#42200117)

    > It's a bit difficult to add more weight lifting because I tended to hurt myself

Did you try slightly lower weight and higher reps? It is worth trying as an experiment. Current scientific literature says that 5-30 reps is the ideal range for gaining muscle mass. And, as you said, the relative heaviness of weights to the person makes a big difference for injury risk.

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