Synopsys tools can use ML, but not for the layout itself, rather tuning variables that go into the physical design flow.

> Synopsys DSO.ai autonomously explores multiple design spaces to optimize PPA metrics while minimizing tradeoffs for the target application. It uses AI to navigate the design-technology solution space by automatically adjusting or fine-tuning the inputs to the design (e.g., settings, constraints, process, flow, hierarchy, and library) to find the best PPA targets.