Hormone replacement would remedy some of these issues. The same can be seen in people under chronic stress or substance abusers.
Estrogen in the brain is neuro-protective and neuro-trophic. The primary source of estrogen in the brain for men is testosterone converted via aromatase.
However, that's speculative. I found no significant studies on point, notwithstanding physician interest. Because some men seek out testosterone, some doctors might be quick to offer it off-label for other conditions.
> Nearly everywhere that tissues of different density or stiffness met, there was a border of scar tissue — a shoreline of damage that seemed to have been caused by the repeated crash of blast waves.
> It was not chronic traumatic encephalopathy, or C.T.E., which is found in football players and other athletes who have been repeatedly hit in the head. It was something new.
Hormone replacement therapy is a game changer for a lot of men who have CTE. I’m a clinical social worker. I’ve worked in emergency medicine, correctional medicine, and now outpatient psychotherapy. I used to think HRT was for ego lifters and old ladies. But I have seen first hand the value of HRT for CTE patients. I’ve seen guys go from three OWIs and unable to manage an entry level job at Lowe’s to law-abiding, midlevel executive at national corporations within months of starting on HRT.