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Re:Supreme Court blocks controversial Purdue Pharma opioid s... by boxed on Friday June 28, 2024 @03:55AM (#40818619)
The nicotine is what makes it addictive, but everything else makes it deadly.

This distinction is well known here in Sweden where we have snus, and also lower rates of lung cancer and cigarette use than the rest of Europe by a LOT.

Re:Supreme Court blocks controversial Purdue Pharma opioid s... by daemin on Friday June 28, 2024 @06:02AM (#40819173)
Though at the same time I would wager a larger rate of gum disease and mouth cancer than the rest of Europe by a lot.
Re:Supreme Court blocks controversial Purdue Pharma opioid s... by bookaway on Friday June 28, 2024 @08:26AM (#40819942)
Going by a quick skim of the 2022 WHO oral health numbers, Sweden[0] doesn't seem significantly worse off oral-health wise than Germany, Holland, or the UK. In fact it's oral cancer incident rates appear a bit better. Though the UK doesn't have great cancer incident rates, it's periodontal disease rate seem to be significantly lesser than the other three (perhaps due to close monitoring as a result of the "bad British teeth" stereotype).

Sweden male tobacco use percentages are slightly higher than the other three countries, which might be a function of the population additionally using non-cigarette tobacco substitutes perhaps as was mentioned by others.

[0] https://cdn.who.int/media/docs/default-source/country-profil...

Re:Supreme Court blocks controversial Purdue Pharma opioid s... by boxed on Monday July 01, 2024 @03:52AM (#40843501)
Not cancer. Because it's, again, not the nicotine that causes the cancer. Snus does NOT increase cancer risk.

It decreases cavities by a lot (presumably because the bacteria doesn't like the environment anymore), but also destroys your gums. All in all, depending on your dosage it could be a wash or even positive for your oral health.

It's absolutely disgusting, but it's not dangerous :P

Re:Supreme Court blocks controversial Purdue Pharma opioid s... by EnigmaFlare on Friday June 28, 2024 @06:26AM (#40819278)
It's not known in Australia where you have to have a prescription to buy a vape but can buy cigarettes freely. Apparently they're relaxing the prescription requirement later in the year but still only pharmacies will be allowed to sell them.
Re:Supreme Court blocks controversial Purdue Pharma opioid s... by brobdingnag_pp on Friday June 28, 2024 @06:49AM (#40819386)
That is not true. It is the interaction of nicotine with various monoamine oxidase inhibitors that makes tobacco smoking addictive, to an extent that it could be stated that it is the MAOIs entirely causing the addictive behaviour: the exact same MAOIs are also found in coffee, after all.

Why are nicotine pouches and vapes addictive, then? The answer lies in the flavourings, which themselves have psychoactive properties, likely also through MAO inhibition.

Re:Supreme Court blocks controversial Purdue Pharma opioid s... by camgunz on Friday June 28, 2024 @07:09AM (#40819461)
God this Gwern junk will never die. There's tons [0] of evidence that nicotine is addictive on its own.

> Why are nicotine pouches and vapes addictive

It's the nicotine.

[0]: https://duckduckgo.com/?q=nicotine+addictive+site%3Anih.gov&...

Re:Supreme Court blocks controversial Purdue Pharma opioid s... by Aerroon on Friday June 28, 2024 @08:57AM (#40820184)
I'm not here to argue, but all top 5 links for me are about smoking. I've not heard of people being addicted to nicotine patches for example, especially non-smokers.
Re:Supreme Court blocks controversial Purdue Pharma opioid s... by ck425 on Friday June 28, 2024 @11:30AM (#40821673)
I looked into this previously, though it was a while ago so I no longer have the sources to hand. Nicotine is still addictive on it's own but when given to non-smokers in a non-tobacco form it's notably less addictive than smoking. Still addictive but far closer to coffee than cigarettes.

Some of this can be explained by different consumptions methods. For example in lozenges, gum and patches nicotine enters the bloodstream much slower than smoking or vaping so even if you consume the same overall amount the peak is lower slowing adaption. But that couldn't explain it entirely.

Re:Supreme Court blocks controversial Purdue Pharma opioid s... by camgunz on Friday June 28, 2024 @11:13AM (#40821451)
Nicotine Addiction: Neurobiology and Mechanism: https://pubmed.ncbi.nlm.nih.gov/32322429/

Neurophysiology of Nicotine Addiction: https://pubmed.ncbi.nlm.nih.gov/22454789/

Re:Supreme Court blocks controversial Purdue Pharma opioid s... by brobdingnag_pp on Thursday July 04, 2024 @06:29PM (#40878573)
Re:Supreme Court blocks controversial Purdue Pharma opioid s... by boston_clone on Friday June 28, 2024 @10:00AM (#40820675)
Re:Supreme Court blocks controversial Purdue Pharma opioid s... by boston_clone on Friday June 28, 2024 @10:00AM (#40820682)
No, it's because nicotine is an addictive chemical.

https://www.fda.gov/tobacco-products/health-effects-tobacco-...

Re:Supreme Court blocks controversial Purdue Pharma opioid s... by boxed on Monday July 01, 2024 @03:54AM (#40843513)
You will have to supply something to back up such a wild statement. Nicotine has been shown to be extremely addictive all the way from humans down to single neurons in a petri dish, for decades.