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Re:Ask HN: Have you tried weight loss drugs? by palata on Sunday May 26, 2024 @05:32PM (#40485573)
What about eating healthier and doing more sport? I heard it works pretty well.
Re:Ask HN: Have you tried weight loss drugs? by muzani on Sunday May 26, 2024 @08:04PM (#40486429)
Sports is actually extremely inefficient when you look at the science. However, when you look at anecdotes, it seems to be consistently impactful. I think it's more an issue with how we're calculating calories out.
Re:Ask HN: Have you tried weight loss drugs? by yahoobing on Sunday May 26, 2024 @08:43PM (#40486623)
It will be hard to pick apart why. Muscles increase metabolism plus I suspect after a workout you feel like protein not carbs/sugar. You eat that and feel full. Then there is plain old confounding of people who have a good diet and people who exercise.
Re:Ask HN: Have you tried weight loss drugs? by slayerjain on Sunday May 26, 2024 @11:24PM (#40487315)
I think weight loss is more than just calories in/out. Maybe our body reacts to adapt to situations and tried to change the body shape to make it easier for itself. So I think healthy habits are more important and can depend on genetic history too.
Re:Ask HN: Have you tried weight loss drugs? by jimkleiber on Monday May 27, 2024 @01:13AM (#40487764)
I think emotions are a huge part of weight gain and loss and yet most Western medicine seems to almost completely ignore the impact of emotions on the body. Try eating a lot of food when sad—it's hard to take even a bite. Yet it's hard to even realize just how much one is eating when anxious.

I also imagine the emotions impact digestion and storage of fats and a lot more, basically adapting our bodies to our perceived environments, so it kinda baffles me that we don't study the emotional impact more.

Re:Ask HN: Have you tried weight loss drugs? by slayerjain on Monday May 27, 2024 @11:23AM (#40491587)
Yes, I agree. I feel we are definitely missing out.
Re:Ask HN: Have you tried weight loss drugs? by muzani on Monday May 27, 2024 @09:16PM (#40496436)
A clear example is something like cortisol. It damages your body to give you a short term advantage to survive a situation.

Being under stress might make you burn lots of calories, but stress ends up being weight gain in the long term because the body tells you to save up more energy for next time.

Re:Ask HN: Have you tried weight loss drugs? by xmonkee on Monday May 27, 2024 @01:50AM (#40487963)
I am fairly certain I know the answer to this. They normally do these kind of studies on untrained humans, because the point is to prescribe (or not) exercise to people who need to lose weight, which are typically not athletes. The anecdotal success comes from people who play sports (tautologically). The problem is you cannot compare across these two groups because the metabolism and sheer volume of exercise is not comparable. Even a semi serious athlete will put in 5-6 hours of intense training a week. And their bodies are much more efficient, so they can burn way more calories in the same time. This is NOT the same as “Brisk walk and lift some weights 3-4 times a week” they prescribe the study group in a study of untrained athletes. Not even close.
Re:Ask HN: Have you tried weight loss drugs? by muzani on Monday May 27, 2024 @06:18AM (#40489380)
I mean the typical advice I get is 1 hour of running burns as much calories as one large slice of pepperoni pizza (~700 cal). Trained or untrained, this seems off by a lot.
Re:Ask HN: Have you tried weight loss drugs? by xmonkee on Wednesday May 29, 2024 @07:26PM (#40518343)
Why does it seem off? It's hard to measure calories when running, but with cycling we have power meters which are incredibly precise, and you will burn around 700 calories an hour (as a beginner). Trained athletes can burn maybe double of that.
Re:Ask HN: Have you tried weight loss drugs? by muzani on Thursday May 30, 2024 @05:53AM (#40521885)
Because it burns off about a whole large pizza's worth, rather than one slice, and I'm not trained.
Re:Ask HN: Have you tried weight loss drugs? by d1sxeyes on Monday May 27, 2024 @08:18AM (#40490085)
Folks who can be bothered to put in the effort to commit to regular exercise are more likely to be able to be disciplined about what they eat. Levels of exercise are probably pretty well correlated with folks who are serious about their weight.
Re:Ask HN: Have you tried weight loss drugs? by slayerjain on Monday May 27, 2024 @12:52PM (#40492489)
What do you think about sports (say badminton) compared to treadmill or cross-trainer for cardio?

If I end up burning the same amount calories? Because I find it much easier to burn calories playing badminton compared to treadmill..

Re:Ask HN: Have you tried weight loss drugs? by refurb on Monday May 27, 2024 @12:56AM (#40487680)
The same thing as “don’t have unprotected sex and AIDS will go away”.
Re:Ask HN: Have you tried weight loss drugs? by palata on Monday May 27, 2024 @11:07AM (#40491436)
I think it is a bit different: I believe that a big reason for AIDS is lack of education about it and lack of access to protections.

Whereas in order to get weight loss drugs you need access to it.

Re:Ask HN: Have you tried weight loss drugs? by k8svet on Monday May 27, 2024 @12:15PM (#40492144)
I have unprotected sex all the time. I'm on prep. Maybe if I was on semaglutide I could eat carbs with out turning into a monster that wants to eat every cinnamon roll in existence. Idk.
Re:Ask HN: Have you tried weight loss drugs? by p00dles on Monday May 27, 2024 @01:46AM (#40487934)
This post is an “Ask HN” about trying weight loss drugs. I don’t think a comment suggesting that people who want to lose weight have low self-discipline and are lazy is very helpful.
Re:Ask HN: Have you tried weight loss drugs? by sk11001 on Monday May 27, 2024 @03:48AM (#40488607)
The main mechanism is [eat less] --> [lose weight].

Some people find it difficult to eat less, hence the drugs to suppress appetite.

Re:Ask HN: Have you tried weight loss drugs? by palata on Monday May 27, 2024 @09:16AM (#40490442)
I would think that the main mechanism is that if you "use" more than you eat, then you lose weight. You have two levers to lose weight: "use more" and "eat less". And then there is the part where not everything you eat is egal, so "eat better", somehow.
Re:Ask HN: Have you tried weight loss drugs? by sk11001 on Monday May 27, 2024 @10:08AM (#40490849)
Technically correct about the balance, but practically people overestimate the amount you can burn with extra activity. The main reason to exercise while losing weight is that if you do resistance training, you preserve more of your muscle and lose predominantly fat - it’s not to burn more calories.

And I disagree about emphasising “better” instead of “less”. “Better” than doesn’t lose weight.

Re:Ask HN: Have you tried weight loss drugs? by naveen99 on Monday May 27, 2024 @10:33AM (#40491100)
Why estimate and not just calculate ? It’s not a hard calculation, walking calorie burn calculators are reasonably accurate. Walking just takes time, which you may value a little higher than burning calories.
Re:Ask HN: Have you tried weight loss drugs? by palata on Monday May 27, 2024 @01:23PM (#40492776)
> “Better” than doesn’t lose weight.

So you're saying that feeding oneself exclusively with chocolate will has the same result as feeding oneself with vegetables? Sounds counter-intuitive.

Re:Ask HN: Have you tried weight loss drugs? by sk11001 on Monday May 27, 2024 @02:37PM (#40493356)
Let's say that you eat n calories of junk food every day (maybe that's all you eat or a part of your diet). Replace those with n calories of healthy foods. Great - you've probably made a good change for your health long term. But you haven't made progress towards losing weight because your calories are the same.
Re:Ask HN: Have you tried weight loss drugs? by palata on Monday May 27, 2024 @06:11PM (#40495239)
Now say you eat exclusively chocolate when you are hungry, during the whole day. And let's compare that to a day where you eat exclusively vegetables when you are hungry.

Will you have eaten the same amount of calories both days?