It can entirely depend on your family/friend circle. For me and mine, In-n-Out is expected, weddings are happening in the locality of one of the families, many are day trips.

Other people's family and friends will have multiple destination weddings, etc.

Still suspect it's not a major component, kids can only have so many grandparents after all.

Is there a regional component to this?

Some of the “meh, missing two weeks a year for vacations isn’t a big deal” attitudes in this thread are very surprising to me, also as a midwesterner.