You may labor under a misapprehension here; if I met Yahweh on the road, I would do my level best to kill it. But I was raised with that book, and still remember enough to play with the toys in it when I want to; if we're talking 1950s sf twists like "the aliens were fellow children of God all along!" then those are the toys with which we're playing.

That aside, of course we're making assumptions. But if we don't choose to either be bound by the assumptions we've already made or re-evaluate them, then we're playing with dolls rather than worldbuilding. Your pastimes are of course your own business, but it's been a long time indeed since I graduated from the former to the latter.

(Not that I mind space opera, when it focuses on the character-driven stories it's best suited to tell - trying to figure out how a TARDIS works misses the point entirely, while "The Doctor's Wife" is beautiful. But you mentioned science fiction, and my current standard there is set by Children of Time and Blindsight.)