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A comment on The history behind aspirin 81. Parent comment
325mg is 5 "grains".
"A grain is a unit of measurement of mass, and in the troy weight, avoirdupois, and apothecaries' systems, equal to exactly 64.79891 milligrams"
https://en.wikipedia.org/wiki/Grain_(unit)
81mg = 1.25 grains.
What ends up happening is a big study is done on an existing formulation of an old drug, results look good, and then you have to ask yourself: do you mess around with the dosing to get a round number, or go with what's been proven?
325mg is 5 "grains".
"A grain is a unit of measurement of mass, and in the troy weight, avoirdupois, and apothecaries' systems, equal to exactly 64.79891 milligrams"
https://en.wikipedia.org/wiki/Grain_(unit)
81mg = 1.25 grains.
What ends up happening is a big study is done on an existing formulation of an old drug, results look good, and then you have to ask yourself: do you mess around with the dosing to get a round number, or go with what's been proven?