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A comment on The history behind aspirin 81. Parent comment

Re:The history behind aspirin 81 by jcul on Sunday November 26, 2023 @06:08PM (#38426078)
In Ireland, I'm sure I've seen 325mg doses of aspirin and been puzzled by it. I assumed it was just a little bit stronger than paracetamol. While that's probably true, I can see now it's a bit arbitrary too.

Though maybe I'm misremembering or thinking of aspirin someone brought from the US. When I look up one of the most common asiprin brands here, it seems it is 300mg, not 325.

https://phelans.ie/products/dispirin-direct-tablets-24s

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Re:The history behind aspirin 81 by Scoundreller on Sunday November 26, 2023 @06:13PM (#38426107)
They are round units, in a dinosaur apothecary system.

325mg is 5 "grains".

"A grain is a unit of measurement of mass, and in the troy weight, avoirdupois, and apothecaries' systems, equal to exactly 64.79891 milligrams"

https://en.wikipedia.org/wiki/Grain_(unit)

81mg = 1.25 grains.

What ends up happening is a big study is done on an existing formulation of an old drug, results look good, and then you have to ask yourself: do you mess around with the dosing to get a round number, or go with what's been proven?

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Re:The history behind aspirin 81 by FabHK on Sunday November 26, 2023 @10:01PM (#38427591)
That’s what the article is all about.
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