mRNA vaccines is the only one that really "pops" for me. The rest are just iterations on what we've already had, but more efficient/less costly/etc. Nothing really revolutionary, only the same old but better.

In that vein, CRISPR, and how it enables individuals to pursue genetic modification and xenobiology/botany, is one that's being utilized right now to make a lot of very cool stuff (one that comes to mind is the S. Mutans strain that doesn't produce lactic acid). But it's still a very involved and very chaotic process that doesn't allow innovations to rocket off.

Most things are iterations on what you already had. Transistors were just an iteration on tubes, but give it 50 years and…

I think the most world changing tech of the last 20 years is the smartphone.

I think of the smartphone as a culmination of many technologies. Efficient broadband wireless radio, efficient and powerful microchips, GPS systems, camera technology, display technology, battery technology, etc, and of course the software to make it all work.

All of those come together to make a powerful, easy to use, portable computer that enables its user to do so many things in so many places there were not possible before.