To your point, I think that what you describe is also a common cause for depression. As Freud said (paraphrasing): most of my patient's aren't mentally ill, they just haven't learned how to live well. There is much to be said for the idea that psychological needs are (mostly) physiological needs like sleep, food, water and exercise. If we extend that to include social needs like love, security, a healthy sex life, stimulating conversation and adventure, we start to approach a notion of transcendence.