That’s behind Type 1 diabetes. The headline suggests Type 2 is the topic?
Long time T1D here... ugh, this is bad news on top of all the issues that the world in general is experiencing around type 2 diabetes. Add to this that covid isn't going away and we're apt to experience a few more major strains that affect the population at large expect to see the diabetes crisis get far worse.
Will end up being another long term health care crisis unless we can find some way to protect against the behavior. Diabetic care is expensive, in the US directly, but even in universal healthcare countries, it is a very material, time, and effort requiring illness that needs continuous treatment and monitoring. Especially in the case of T1 where insulin and constant blood sugar monitoring is needed.
Vaccines don't cause circulating S protein at any levels that could cause damage to organs.
We can measure some S in the blood after vaccination, but it is at levels of femtograms per milliliter. Spike is confined within the cells that the vaccine enters and isn't sprayed around the circulatory system by the vaccine. What is displayed on the surface of those cells is the T-cell epitopes after the protein has been chopped up by proteases and those relatively short sequences are displayed on MHC for the immune system. The spike that leaks out is probably only due to those cells being lysed in the lymph nodes.
That is many orders of magnitude less of an exposure than someone who is infected and has literally billions of virus particles floating around expressing spike on their surface.
The vaccine won't cause any effects via circulating spike, that is just bullshit that was being spread early in the vaccine rollout. The reactions to the vaccine are going to be autoimmune-mediated.
It's easy to read something and repeat it back - but if that's it, I want the original source of info to check for myself - I don't want an intermediary.
https://www.reuters.com/article/factcheck-vaccine-safe-idUSL...
This is the actual scientific article:
https://academic.oup.com/cid/article/74/4/715/6279075?login=...
Sorry, after 2.5 years I misremembered pg/mL as fg/mL but its all too small to matter.
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.0...
You don't need circulating spike to explain vaccine caused myocarditis. The vaccine produces an immune response. The initial immune response are low affinity antibodies. Those antibodies can sometimes target host cells accidentally. As somatic hypermutation happens in the months following the exposure to the antigen the high affinity antibodies that form (and which are boosted by a 2nd exposure to the antigen) are less likely to accidentally target host cells. This is presumably why I had a complete recovery after around 2 months and all I needed was an NSAID to tamp down the inflammation.
The obvious objection to that article is that correlation is not causation. It needs to be replicated, and there needs to be more than just speculation about a mechanism. There already exists a very well-known mechanism (autoimmunity) for the alternative explanation.
I am taking your comment to mean that you think it's not a credible paper? That's the main thing I wanted to know, it seems like you believe the paper implies something very unlikely and so authors have an agenda?
“ The authors noted that research has shown that coronavirus-binding via angiotensin-converting enzyme 2 (ACE2) receptors damages islet cells in the pancreas and may lead to diabetes.”
Hmm so the corona virus itself can damage the pancreas .. and possibly induce diabetes .
Also the MRNA vaccines can damage the pancreas by a similar mechanism. Interesting this part is left out of the posted article.
“ Binding of circulating S protein to angiotensin-converting enzyme 2 (ACE2) (that is critical for the renin–angiotensin system balance) or to other targets, along with the possibility of molecular mimicry with human proteins, may contribute to the vaccination-related AEs. The benefit–risk profile remains in favor of COVID-19 vaccination, yet prospective pharmacovigilance and long-term monitoring of vaccinated recipients should be a public health priority.”
So imagine youth getting the vaccine … and then later getting the virus (like most of the country did). Both have a risk for damaging the pancreas.
https://www.cell.com/trends/molecular-m