The way the Supreme Court recently changed patent law [3] for software has definitely had a positive effect for APS development. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769814/ [2] https://patents.google.com/patent/US20150306314 [3] https://en.wikipedia.org/wiki/Alice_Corp._v._CLS_Bank_Intern...
That's good news, right? That means that everything that people now come up with has well-documented prior art?
If you need a really optimal control trajectory minimizing or maximizing for some parameter, you are willing to do the system identification necessary for it to work, and you don't much care whether an electrician can understand how it works model-based controls are much better. as /u/Communitivity mentioned so called 'model based control' (which is an umbrella of techniques) is a much more powerful tool.
From Wikipedia:"A proportional–integral–derivative controller (PID controller or three-term controller) is a control loop mechanism employing feedback that is widely used in industrial control systems and a variety of other applications requiring continuously modulated control. A PID controller continuously calculates an error value e(t) as the difference between a desired setpoint (SP) and a measured process variable (PV) and applies a correction based on proportional, integral, and derivative terms (denoted P, I, and D respectively), hence the name."
Getting PID control loops to work has a lot of research behind it, but it's still hard to get right with new hardware. I would imagine a PID control loop involving organics (wetware) would be much order, and harder still a PID control loop in organics with life-threatening failures possible.