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A comment on Melatonin, a sleep aid, is a surprising treatment for food waste. Parent comment

Re:Melatonin, a sleep aid, is a surprising treatment for foo... by orev on Friday August 04, 2023 @05:16PM (#37005993)
Never take Tylenol PM to sleep, unless you also have a reason to need a painkiller (acetaminophen). Acetaminophen is toxic to the liver and can cause liver failure if overdosed. A regular diphenhydramine (Benadryl) is the just the PM part without the extra risk (except that has its own risks).
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Re:Melatonin, a sleep aid, is a surprising treatment for foo... by jansan on Friday August 04, 2023 @06:03PM (#37006457)
It has a therapeutic index of 10, which is quite low (easy to overdose). I stopped taking Paracetamol almost completely after learning what it can to your body.

Also, there was a story about the developer of DirectX who alledgedly overdoesed on Paracetamol/Tylenol:

https://web.archive.org/web/20201223122742/https://www.wsj.c...

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Re:Melatonin, a sleep aid, is a surprising treatment for foo... by nalllar on Friday August 04, 2023 @10:10PM (#37008288)
cumulative exposure to dihenhydramine is linked to dementia so it also shouldn't be used regularly
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