Modern Hunter-Gatherers Have Thriving Gut Microbiome, Compared with Californians

Re:Modern Hunter-Gatherers Have Thriving Gut Microbiome, Com... by AndrewKemendo on Monday June 26, 2023 @06:07PM (#36486540)

Study after study fail to disprove the hypothesis that gut microbiome diversity is a strong correlate with longevity.

Here's a meta study for you:

Here we introduce the MicrobiomeHD database, which includes 28 published case–control gut microbiome studies spanning ten diseases. We perform a cross-disease meta-analysis of these studies using standardized methods. We find consistent patterns characterizing disease-associated microbiome changes.

What more do people want? Why is this something people fight?

[1]https://www.nature.com/articles/s41467-017-01973-8

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Re:Modern Hunter-Gatherers Have Thriving Gut Microbiome, Com... by CrHn3 on Monday June 26, 2023 @10:59PM (#36488395)

I’m not sure what you take away from that meta analysis, but to me it does not seem to be about diversity as much as which groups of bacteria are associated with general improved health outcomes and disease. If you have more alpha diversity because you have more pathogenic strains, it does not necessarily mean it’s better.

Some studies have found no differences in alpha diversity[1] when looking at outcomes like longevity. Maybe alpha diversity is the byproduct of healthy flora but it could be possible to engineer a microbiome that was more advantageous for a given population that was less diverse.

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762384/

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