Work from Home - Throughout the ages of man, I would tend to believe that more work has been done at home than at any notion of modern workplace. Farming, milling, iron working, etc. have all historically been performed by small tradesmen working out of their homes. "Go to Joe's house if you want your horses shoed."
Home School - Again, I would argue that far more children throughout history are being school at home than in a western notion of traditional school. I would wager that even today, more kids are currently "at home" schooling across the globe than in a modern school.
Interest Rates - Maybe this one is a reasonable notion of "unnatural". But again, throughout all time, bartering has dominated merchant exchanges and simple currency exchanges (through precious metals). There has probably always been a notion of interest rates in all this, but what you're describing is more about the federal reserve's interest rates and fractional banking, which is quite a modern invention.
In all, I don't think anything about work from home, home schooling or making transactions with neighbors is unnatural. If anything, it's the most natural way that society has worked and existed throughout history.
All of this has significant IRL contact with the wider world. Modern knowledge worker WFH does not.
In what way is WFH 'unnatural'?
I would avoid extrapolating your own WFH experience to others.