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A comment on Ketamine no better than placebo at alleviating depression, unusual trial finds. Parent comment

Re:Ketamine no better than placebo at alleviating depression... by arthur2e5 on Monday May 22, 2023 @09:09AM (#36030968)
The study actually shows ketamine works as well with anesthetia (45%) as without (40%), if you read the non-anesthetia study linked in https://news.ycombinator.com/item?id=36030251.

(Of course you can argue they are not using enough K at the 0.5 mg/kg mark, because disccociation starts at 1 to 3 mg/kg per StatPearls.)

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Re:Ketamine no better than placebo at alleviating depression... by PragmaticPulp on Monday May 22, 2023 @09:30AM (#36031211)
> Of course you can argue they are not using enough K at the 0.5 mg/kg mark, because disccociation starts at 1 to 3 mg/kg

Dissociation isn’t necessary for the antidepressant effect, according to studies. In fact, many of the more responsible clinics target longer duration, lower peak dose infusions for this reason.

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Re:Ketamine no better than placebo at alleviating depression... by arthur2e5 on Tuesday May 23, 2023 @11:06AM (#36045362)
Well, yeah. But the parent comment is insisting that the spiritual bits is doing something, and I was just way too lazy to look for a dose response study.
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