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Re:Exercise Increases Number of Immune Cells in Cancer Patients by ActorNightly on Tuesday May 02, 2023 @03:38PM (#35793002)
Its even simpler.

Exercise (specifically, aerobic type) is the main thing you need. A good exercise regime gives you a lot of leeway in the diet aspect especially if you don't overeat (since your caloric burn will be high enough on the regular to not have to deal with issues like too much carbs). It also helps you sleep as you get tired and can fall asleep easier, and reduces stress levels, which is very important in regards to longevity.

There also have been studies that link brain function deterioration with lack of oxygen, and people with higher VO2max values are at a lower risk of cognitive decline.

Something as simple as cycling to the office instead of taking the car can have extremely positive effects.

Re:Exercise Increases Number of Immune Cells in Cancer Patients by Swizec on Tuesday May 02, 2023 @03:51PM (#35793165)
Don’t forget all the evidence suggesting adult neurogenesis specifically from running.

As for VO2max, Levitt had a longevity researcher on his podcast who found that a high VO2max (used as a proxy measure) is causally related with higher impacts on 5 year all cause mortality than smoking. In the good direction. As in: being in shape reduces your risk of death more than smoking increases it.

Sauce: https://freakonomics.com/podcast/adding-ten-healthy-years-to...

Re:Exercise Increases Number of Immune Cells in Cancer Patients by swalling on Tuesday May 02, 2023 @03:55PM (#35793230)
It's not just a longterm effect of VO2max improvements, which is a physiological metric that is quite slow to improve and realistically has upper limits based on your age and sex. It's also that aerobic exercise acutely improves brain function. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256523/#:~:tex...
Re:Exercise Increases Number of Immune Cells in Cancer Patients by o_____________o on Tuesday May 02, 2023 @04:05PM (#35793355)
Figured that would be Peter Attia.

https://peterattiamd.com/podcast/

His podcast is amazing but can be dense and technical at times. He's evidence based and would probably fit in with the HN crowd.

Re:Exercise Increases Number of Immune Cells in Cancer Patients by matwood on Tuesday May 02, 2023 @04:19PM (#35793553)
I enjoy listening to Attia talk about his longevity research. He's why I finally started doing IF, and someone I looked to when I moved from power lifting (can't do it forever lol) to a more longevity based exercise program.

Then I randomly got really into jiu-jitsu because why not.

Re:Exercise Increases Number of Immune Cells in Cancer Patients by pastor_bob on Tuesday May 02, 2023 @05:06PM (#35794201)
Peter Attia got me into having a weekly MRI and wearing a dexcom 24/7. Costly, but great stuff.
Re:Exercise Increases Number of Immune Cells in Cancer Patients by o_____________o on Tuesday May 02, 2023 @05:44PM (#35794639)
Weekly, seriously? What's the background with that?
Re:Exercise Increases Number of Immune Cells in Cancer Patients by david2ndaccount on Tuesday May 02, 2023 @03:56PM (#35793237)
Cycling has its own risks as it can reduce bone density if you cycle instead of walking or other forms of exercise.
Re:Exercise Increases Number of Immune Cells in Cancer Patients by decodebytes on Tuesday May 02, 2023 @04:06PM (#35793367)
How much Cycling do you have to do for that to become a credible risk though? I am imaging quite a bit more than a daily commute.
Re:Exercise Increases Number of Immune Cells in Cancer Patients by nradov on Tuesday May 02, 2023 @04:29PM (#35793731)
Cycling doesn't directly cause loss of bone mineral density. Ride as much as you like.

The issue is that some people use cycling as their only form of exercise. For bone health you need to mix in other high impact exercises such as running and weightlifting.

Re:Exercise Increases Number of Immune Cells in Cancer Patients by ActorNightly on Tuesday May 02, 2023 @05:51PM (#35794727)
Make every other ride a mountain bike ride and you will have no issues with bone density.
Re:Exercise Increases Number of Immune Cells in Cancer Patients by orev on Tuesday May 02, 2023 @03:56PM (#35793241)
You can’t outrun a bad diet. It takes a lot of exercise to burn off excess calories, and virtually no effort to simply not consume them. I understand that health is more than just calories, and you can come to the same conclusion about other bad things like trans fats, alcohol, etc.

If someone had to choose only one thing to do for health, a healthy diet is far more important than exercise.

Re:Exercise Increases Number of Immune Cells in Cancer Patients by lukemercado on Tuesday May 02, 2023 @04:10PM (#35793426)
> It takes a lot of exercise to burn off excess calories, and virtually no effort to simply not consume them.

> and virtually no effort to simply not consume them.

I don't think this is true. The executive function required to manage the dopamine cycle that food generates is incredibly taxing. I honestly think this is a result of our food systems being incredibly optimized to drive purchasing decisions...

Separately, this reminds me that I should eat some veggies.

Re:Exercise Increases Number of Immune Cells in Cancer Patients by cowmoo728 on Tuesday May 02, 2023 @04:28PM (#35793702)
Exercise moderates negative feelings and hormones and often causes people to maintain a better sleep and diet routine. Everything in life becomes easier with a light/moderate regular exercise routine. It's inseparable from diet.
Re:Exercise Increases Number of Immune Cells in Cancer Patients by matwood on Tuesday May 02, 2023 @04:15PM (#35793493)
I agree, but we need to stop with the one thing. A decent diet is important, and so is cardio. And, so is strength. A person will lose a % of muscle/strength each year after age 50 or so. The higher base you start with the more strength a person will have as they get older, which helps prevent falls and other old age issues.
Re:Exercise Increases Number of Immune Cells in Cancer Patients by QuercusMax on Tuesday May 02, 2023 @04:24PM (#35793639)
This is only true to a point. When I was cycling 20 miles 5x per week, I literally couldn't eat enough to avoid losing weight. (This was not a problem, I've never been thin.)
Re:Exercise Increases Number of Immune Cells in Cancer Patients by Fricken on Tuesday May 02, 2023 @04:37PM (#35793837)
Yes, when I switch into training mode, the fat melts off in short order (I've never accumulated more than 20 pounds of unwanted mass, and when I did it was following a broken leg and 2 years spent largely sedentary)

In the past I've toned my training down due to exhaustion, not from the physical output but from having to constantly be shoving calories down my throat.

Re:Exercise Increases Number of Immune Cells in Cancer Patients by swalling on Tuesday May 02, 2023 @05:33PM (#35794531)
This is very common among endurance athletes. It's extremely difficult to consistently recover from a 1,000-2,000 calorie deficit every time you do a weekly long run or ride. Glycogen reabsorption is optimally effective for only a relatively brief time period post-exercise and there are upper limits on your rate of glycogen resynthesis.
Re:Exercise Increases Number of Immune Cells in Cancer Patients by Fricken on Tuesday May 02, 2023 @04:30PM (#35793734)
You can't outrun a bad diet, but a bad diet can give you the runs.
Re:Exercise Increases Number of Immune Cells in Cancer Patients by bitL on Tuesday May 02, 2023 @04:23PM (#35793631)
Switching to carnivore diet gives you 2lb/1kg weight loss a week without any exercise and any feeling of hunger or weakness (assuming you are overweight).
Re:Exercise Increases Number of Immune Cells in Cancer Patients by sudosysgen on Tuesday May 02, 2023 @04:01PM (#35793316)
While you can't easily burn off excess calories, a good amount of muscle mass can significantly increase your metabolic rate as well, so there are effects from repeated exercise beyond just calorie consumption.
Re:Exercise Increases Number of Immune Cells in Cancer Patients by kriops on Tuesday May 02, 2023 @04:17PM (#35793517)
Citation needed because “significantly”. Studies I have seen in this (not my field) indicate that the effect is measurable, but basically negligible.

The ancestor comment saying to do cardio is right. Strength training is also important for health, but for different reasons (motor function, bone density, etc.). The act of strength training also burns some calories, regardless of resultant muscle mass.

Re:Exercise Increases Number of Immune Cells in Cancer Patients by sudosysgen on Tuesday May 02, 2023 @04:37PM (#35793846)
Yes, I do have a citation : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931407/#!po=8....

Every extra kg of muscle is estimated to contribute 21kcal/day to the RMR. If you put on, say, 15kg of muscle over a few years (quite doable if you are very sedentary and have low muscle mass), that's an extra 300kcal/day. Add in 30 mins of biking a day, and say 100 cal from strength training on average, that's a good 600-700 calories per day!

Re:Exercise Increases Number of Immune Cells in Cancer Patients by ActorNightly on Tuesday May 02, 2023 @05:50PM (#35794716)
Bad diet, as in Mcdonalds every day and lots of sugar, is going to be bad for you even with exercise, but thats because you probably aren't getting the nutrients that you need.

The big issue with diets is that people eat too much carbs, and if you aren't burning those carbs for energy, this is where problems happen. Healthy regiment of exercise will help greatly with this, giving you the option to eat tasty foods with carbs and maintain a good weight without any problems.

Re:Exercise Increases Number of Immune Cells in Cancer Patients by pengaru on Tuesday May 02, 2023 @10:47PM (#35797150)
> You can’t outrun a bad diet.

It gets even worse, when the obese try to outrun a bad diet they not only fail but they often injure themselves in the process.

It always pains me to see obese people out on the trails beating themselves up in an obviously misguided but respectable effort to lose weight.

Re:Exercise Increases Number of Immune Cells in Cancer Patients by mft_ on Tuesday May 02, 2023 @04:03PM (#35793331)
I'm not disagreeing that aerobic exercise is important and beneficial, but to add: there is also data correlating other exercise behaviours (stretching, strength training) with positive health and longevity outcomes. Also, quite significant benefits can be achieved via HIIT, which is anything but aerobic.
Re:Exercise Increases Number of Immune Cells in Cancer Patients by graypegg on Tuesday May 02, 2023 @04:05PM (#35793356)
I can totally vouch for this in my valueless opinion study of n=1.

I’ve always eaten “a little bad” diet. I don’t think I eat too much, and I keep things mostly balanced, but I tend to eat quite late, and carbs and calories was always something I’d just take down without considering totals for a day or week.

Was totally fine when I was walking to work every day, and doing a lot outside.

Early COVID era, with the same diet, I started ticking up in weight, and wasn’t feeling great. Once adding more exercise to my routine I slowly returned to my baseline. Maybe I could be doing better with a better diet, but I was kind of shocked by how much of an effect ~1hr of walking a day had on me.