Re:How Peptide Injections Became the Answer to Everything
by GeoRandel on Saturday March 04, 2023 @10:33AM
(#35021518)
Would BPC-157 be something that could be packaged in a liposome? Everything I've read about liposomal supplements has pointed to it having superior absorption, distribution and bioavailability when compared to injection
Re:How Peptide Injections Became the Answer to Everything
by A_D_E_P_T on Saturday March 04, 2023 @03:35PM
(#35024262)
Yeah, you can incorporate BPC-157 and other small peptides into liposomes.
Liposomal delivery might even work for far larger peptides and proteins. For e.g., there has been quite a lot of research into liposomal insulin: https://pubmed.ncbi.nlm.nih.gov/2226109 and others.
The thing about BPC-157 in particular is that it has, in principle, pretty good oral bioavailability, and it's not clear that it would benefit from liposomal delivery. You'd probably want to run a comparative analysis -- liposomal suspension vs. plain aqueous solution -- which would be expensive no matter how you go about it.
Further, consider insulin. It's typically administered as an aqueous solution injected subcutaneously, and it's absorbed quickly and systemically, with local effects in the near-zero range.
It's possible to make an aqueous solution for SC injection that might have some degree of local efficacy, if it's injected near a target site. This, however, would involve tinkering with the PH of the solution to induce drug precipitation, post-injection, near the injection site. It's complicated, and not the sort of thing that gray market research chemists do.