http://www.keyboard-layout-editor.com/#/gists/8b8dcd36c0abcc... https://gist.github.com/rollcat/8b8dcd36c0abccf430b4160ad899...
I remember using AutoHotKey back then to swap caps lock and CTRL (or was Backspace in there somewhere?) to cycle through my hatcheries and spam larvae injects, since they weren't queue-able at that time.
Backspace (next base cam) inject is still a thing, but it's not really recommended: it tends to send different queens towards different hatcheries, delaying the injects. Again I didn't play WoL so I don't know which keys were re-bindable in the client at the time, but currently you can use almost anything for anything (except you can't change the modifiers like ctrl, shift, alt); those who use base cam inject will sometimes bind it to space.
For two-hands-on-keyboard tasks, relying on layering is good.
For gaming, I make use of a number row.
So you can have keys like escape, enter, ctrl or similar right on the home-row.
For those not familiar, to get down to this low number of keys, some layouts will place modifiers (ctrl, shift, alt, meta) as secondary actions (when the key is held down vs. tapped) on home row keys (asdf, jkl; on QWERTY). The problem is to distinguish a tap from a hold, there's a minimum delay before the key is sent, making it very annoying for fast typists as there may be visible input lag when hitting one of the home row keys.
Another option is moving those keys to bottom row, or moving layers to combos to free thumb keys to for mods or move mods to combos as one shots.
So what I'm saying is use home row hold/tap just for layer selects that will only affect the other hand, and use hold/tap modifiers for programming symbols.
I'd say if you look at a layout like miryoku https://github.com/manna-harbour/miryoku .. in miryoku, the [] keys are one row up from home row, accessed on a layer. Whereas, putting [] on outer columns, your hand has to move and reach over two rows.
That is, I'd emphasise layering brings more keys to within easy access of the fingers (at the cost of added complexity to use the keyboard, - which not everyone has the taste for).