News for hackers. Stuff that matters.
Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by sowbug on Sunday January 01, 2023 @03:13PM (#34210349)
"Instead, iPSCs are taken from adult human cells, usually from a skin or blood sample, and converted into an embryonic-like state."

What would happen if the adult human donor took these embryonic-like cells and reinjected them? Would the person develop the vim and vigor of a young adult?

Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by mjfl on Sunday January 01, 2023 @03:27PM (#34210511)
They would develop widespread teratomas similar to metastatic cancer, and die.

https://en.wikipedia.org/wiki/Teratoma

Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by debenedictis on Sunday January 01, 2023 @03:35PM (#34210580)
That teratoma link has quite disturbing pics.
Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by mariuolo on Sunday January 01, 2023 @03:39PM (#34210609)
> That teratoma link has quite disturbing pics.

From Ancient Greek τέρατος (tératos, “monster”).

Aptly named, I would say.

Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by codethief on Sunday January 01, 2023 @04:58PM (#34211449)
Make sure to also look at the German Wikipedia page. Two words: Teeth and hair.
[dead]
Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by coldtea on Monday January 02, 2023 @05:15AM (#34216292)
We do have a better grasp, but we're still in the "trying various things blindly and see what sticks" stage and will be for some time...
Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by peteradio on Sunday January 01, 2023 @06:00PM (#34212020)
So you're saying superpowers?
Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by api on Sunday January 01, 2023 @08:41PM (#34213231)
The superpower to grow tumors with hair in them.
Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by Sakos on Monday January 02, 2023 @05:22AM (#34216341)
You know what, I think I'll pass.
Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by thefounder on Monday January 02, 2023 @05:51AM (#34216539)
You've got to crack a few eggs to make an omelette
Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by speedylight on Sunday January 01, 2023 @11:07PM (#34214219)
This should NSFW tbh.
Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by whatshisface on Monday January 02, 2023 @02:42AM (#34215392)
For anyone who wants to see the answer without looking at the, uhh, medical images, here's a quote:

"Pluripotent stem cells including human induced pluripotent stem cells have a unique property of being able to generate teratomas when injected in rodents in the research laboratory.[62] For this reason, the so-called "teratoma assay" is one of the gold-standard validation assays for pluripotent stem cells.[63] Because differentiated human pluripotent stem cells are being developed as the basis for numerous regenerative medicine therapies, there is concern that residual undifferentiated stem cells could lead to teratoma formation in injected patients, and researchers are working to develop methods to address this concern.[64]"

Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by echelon on Monday January 02, 2023 @03:37AM (#34215735)
When you think about what the genome encodes, you have to appreciate the finely tuned timing and signalling of developmental biology. As development progresses, cell populations split off and take on different forms, functions, biochemistry, and gene regulation to fit their new purpose.

Our bodies differentiate cells into different lineages precisely when it is developmentally necessary. You don't want to turn the clock in reverse. That's a disease state and a hallmark of cancer.

https://en.wikipedia.org/wiki/Cell_lineage

On the subject of developmental biology, this is a really fun image if you aren't familiar:

http://www2.hawaii.edu/~pine/book1qts/embryo-compare.html

Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by amts on Monday January 02, 2023 @05:17AM (#34216306)
>> You don't want to turn the clock in reverse. That's a disease state and a hallmark of cancer.

Well, you actually do want to turn the clock in reverse. That's a hallmark of the highest so far methodology standard in science: if you want to position that you gained a full understanding of an object, you need to be able to reverse engineer it both in space and time. Many cancers contain senescence associated secretory phenotype (SASP) and senolytic drugs have been researched to be able to neutralize cancer cells as well as senescent cells.

You do want to turn the clock in reverse, only maybe not the whole way back to the embryonic state, but a couple of formal years or decades back to reset the epigenome, and this is exactly what David Sinclair, Vittorio Sebastiano and many others are undertaking now.

Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by mensetmanusman on Monday January 02, 2023 @11:22AM (#34219675)
“That's a hallmark of the highest so far methodology standard in science: if you want to position that you gained a full understanding of an object, you need to be able to reverse engineer it both in space and time.”

We can’t even do this with simple black box game playing AIs, so a new paradigm may be needed.

Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by amts on Monday January 02, 2023 @12:07PM (#34220357)
Oh, with AI game players, can't you just insert a print statement in code to simultaneously log all weights' changes and their accompanying changes in performance etc in a file and get another AI like some multi-parameter regression to search for correlations in it?
Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by trenchgun on Monday January 02, 2023 @05:00AM (#34216208)
> Would the person develop the vim

is this how hackers are born?

Re:Mini Brains Grown from Stem Cells Developed Eye-Like Feat... by danmur on Tuesday January 03, 2023 @03:18AM (#34229128)
It could be much worse, they could develop emacs instead of vim