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Re:Ancient virus may be protecting the human placenta by wan_ala on Monday November 28, 2022 @01:30AM (#33770403)
Does anybody know if there is a less vague date than "millions of years ago" as to when this retrovirus started becoming apart of human DNA? Were we even humans at the moment?
Re:Ancient virus may be protecting the human placenta by e40 on Monday November 28, 2022 @03:51PM (#33779425)
I listened to a podcast on this and they said it allowed the placenta to evolve in the first place. That's what I remember. Anyone else?
Re:Ancient virus may be protecting the human placenta by type0 on Monday November 28, 2022 @03:55PM (#33779483)
I've read it in some pop sci book on genetics as well that without retroviruses we wouldn't have placental mammals, it's certainly convincing theory given how weirdly these cells need to behave.
Re:Ancient virus may be protecting the human placenta by SandmanDP on Monday November 28, 2022 @04:07PM (#33779654)
If you can find the source for that I’d love to read about it
Re:Ancient virus may be protecting the human placenta by bpodgursky on Monday November 28, 2022 @04:56PM (#33780417)
I read this theory in The Mom Gene but I'm not sure where it sourced from.
Re:Ancient virus may be protecting the human placenta by shagie on Monday November 28, 2022 @10:00PM (#33783167)
https://whyy.org/segments/the-placenta-went-viral-and-protom...

https://www.pbs.org/wgbh/nova/article/endogenous-retroviruse...

From the NOVA episode which gets to the human related part, (but that whyy article is on the protomammal rather than primate and thus may be of more interest to you).

> All was going as planned until McCoy’s bioinformatics specialist Steve Howes rushed into his lab in 1997 to show him the sequence of a gene they called syncytin, which their work showed was secreted by placenta tissue.

> Before McCoy could go public with his discovery, he needed to figure out exactly what syncytin did, a job he passed to bench scientist Sha Mi, who everyone called Misha. Misha’s experiments seemed to be going as planned until, a few months later, she, too, rushed into McCoy’s lab with findings of her own.

> Syncytin is produced only by certain cells in the placenta, and it directs the formation of the cellular boundary between the placenta and maternal tissue. Approximately one week after fertilization, the egg, now a hollow ball of cells called a blastocyst, implants itself into the uterus, stimulating the formation of the placenta, which provides the fetus with oxygen and nutrients while removing carbon dioxide and other wastes. It also serves as a barrier to prevent infection and keep maternal and fetal blood separate. (Mixing the two could cause a fatal autoimmune response.) The cells in the outer layer of the blastocyst form the outer layer of the placenta, and those in direct contact with the uterus are the only ones that made syncytin.

---

This then links to

Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis https://www.nature.com/articles/35001608

Retroviruses push the envelope for mammalian placentation https://www.pnas.org/doi/full/10.1073/pnas.1121365109

Also the wikipedia page on it: https://en.wikipedia.org/wiki/Syncytin-1 (and all the references that one finds in a science related wikipedia article)

Re:Ancient virus may be protecting the human placenta by cultofmetatron on Monday November 28, 2022 @06:46PM (#33781588)
primates aren't the only placental mammals though
Re:Ancient virus may be protecting the human placenta by _Microft on Monday November 28, 2022 @03:57PM (#33779515)
> About 30 million years ago, a virus infected our primate ancestors and one of its genes got trapped in their genomes.
Re:Ancient virus may be protecting the human placenta by chatmasta on Monday November 28, 2022 @06:10PM (#33781213)
So at +/- 1 million, that's a range of 29-31 million, or three million years. That still seems imprecise, to be fair.

For any virologists out there, is this question similar to estimating the date of a Git commit? Or maybe it's similar to finding the nearest tag to a given commit, where a "tag" is some external reference point for a known age (like a fossil or ice core)?

Re:Ancient virus may be protecting the human placenta by cguess on Monday November 28, 2022 @04:40PM (#33780159)
Literally the first line of the article.