To be clear, I'm trying to explore the idea that individual songs have optimal tunings because they only use certain intervals. So, something more fine grained even then singing for a particular key.
So the compromise we've all settled on is that we play music in the equitempered scale, and only adjust a little bit here and there to exploit perfect tunings in limited, style-dependent ways.
Which is to say: perfect chords are interesting flavor, but at the end of the day kinda boring in isolation; "real" music needs more rules.
(This is also the same mechanism at work when an entire choir singing an unaccompanied piece goes flat without realizing it. Someone will not quite make an ascending interval, and everyone else will adjust to cover it.)
(1) Example: "get up an get out" by Iggy Pop. https://www.youtube.com/watch?v=R1ld5jG3f-M
So basically, a woodwind like a sax will tune a few notes with a piano or whatever, but it's really up to the player to keep playing in tune. I would not even bother trying to autotune or use post-processing; it'll just sound weird.
This is also how you can get a room full of student musicians "tuned" but it still sounds like a disaster.
usually that’s not the case though. typically it’s individual notes. much harder to precisely and accurately modulate tape velocity (especially by hand).
This sort of hybrid tuning is common in barbershop quartet singing as well.
We've had self-tuning instruments for thousands of years. Vocal harmony has almost always been perfectly tuned for its key. Likewise orchestral strings are fretless and can produce perfect intervals. Equitemperment was an innovation in the 17th century because it approximated the perfect intervals very well ("sounded good") but also permitted the ability to simultaneously represent scales based on every note in the circle of fifths ("sounded interesting"). But the "real" chords were always (well, since the late middle ages) understood to be integer ratios.