Overall, really cool idea (dropped my jaw when I first saw it in action), but poorly implemented.
What's rather messy about Nix is nixpkgs with its helper functions all over the place alongside pretty shallow / non-existent documentation (which is unrelated to the language). Thankfully they've started to work on that recently: https://discourse.nixos.org/t/documentation-team-flattening-...
Well, there's Haskell, and I expect any Haskell programmer to be able to pick up Nix very quickly.
Guix has gone with a strict language, Scheme, but I understand they have their own monadic DSL to cope with the peculiarities of following the Nix model. So again, not something that a mainstream language can do well, and even as a Schemer, you're going to have to learn their macro language.
The latest release has included "flakes", promoted from an add-on to an opt-in feature and which, among other things, lets me pin my dependencies and the environment I need to build my private projects. I then don't have to worry about going out of sync with the main package set, and I can share private projects in a (hopefully) fully reproducible way, with people using different versions of nix.