Ingredient in Cough Syrup Could Work as an Antidepressant: Works Like Ketamine

Re:Ingredient in Cough Syrup Could Work as an Antidepressant... by dubswithus on Wednesday May 04, 2022 @03:53PM (#31264999)

I tried it when I temporarily ran out of prescribed ketamine lozenges recently. Half-life is too long and experience is very unpleasant. Not great qualities for a drug that one frequently needs to take after work.

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Re:Ingredient in Cough Syrup Could Work as an Antidepressant... by raun1 on Wednesday May 04, 2022 @07:22PM (#31267154)

Like most dissociatives, it is unpleasant until it "clicks".

Once it clicks, it is just as pleasurable as Ketamine, Methoxetamine, and other related ACHs.

One major difference between DXM and K is that DXM is quite stimulating whereas K is rather subdued and relaxing. If you don't have dissociative experience besides Ketamine, I'm not surprised that trying DXM after K would lead to an unpleasant experience.

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Re:Ingredient in Cough Syrup Could Work as an Antidepressant... by dubswithus on Wednesday May 04, 2022 @09:23PM (#31268219)

I find ketamine to be a mix of stimulation and relaxation.

> Once it clicks, it is just as pleasurable as Ketamine, Methoxetamine, and other related ACHs.

If that was the case recreational users would move exclusively to research chemicals. There is a clear preference. But in some places DXM is much easier to access so that's what people do.

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Re:Ingredient in Cough Syrup Could Work as an Antidepressant... by ineedasername on Wednesday May 04, 2022 @03:57PM (#31265039)

In trials they are mixing it with quinidine or bupropion, which increases the bioavailability so lower doses are effective. Maybe that will help negative effects.

Unfortunately there will probably never be one single silver bullet solution here, but another tool in the tool belt is always useful.

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