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Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by chrisco255 on Friday April 22, 2022 @10:15PM (#31130759)
So vaccinated Nordic ancestry young males have roughly 9 to 28 times more incidents of myocarditis. These same young males have virtually zero risk from Covid. If a young Nordic male has already had Covid and has natural immunity, the mRNA shots add risk with no benefit.
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by renaudg on Saturday April 23, 2022 @12:30AM (#31131407)
> These same young males have virtually zero risk from Covid.

This is a 2 years old belief that's convenient to politicians but has been utterly, comprehensively destroyed by science by now. It needs to die, yesterday.

For one thing, Covid-caused myocarditis is an order of magnitude or two more frequent than vaccine-caused myocarditis, at all ages. The latter also overwhelmingly resolves in a few days without treatment.

For another, there appears to be no such thing as durable "natural immunity" with Omicron. Reinfections are now documented to have happened as closely as 20 days apart !

Finally, not a single week goes by these days without a new study being released that describes "yet another creative way SARS-CoV-2 f*cks up the human body, yay!".

This week I suppose the most interesting development is a new meta-analysis reporting that HALF of people infected with Covid still have symptoms at least four months later (aka Long Covid) https://academic.oup.com/jid/advance-article/doi/10.1093/inf...

In the UK, an estimated 1.3 million people had long Covid as of early 2022, growing by 200K each month.

It was estimated that nearly a quarter million people had dropped out of the job market completely as a result :

https://www.ft.com/content/33444f29-bab1-4655-85b5-c0b1f68d9...

https://www.ft.com/content/8b9166af-2e85-4429-ab1f-362c189e4...

Covid isn't going to immediately kill us all, but it's pretty obvious by now that it's already a mass disabling event, the main unknown being how reversible the neurological + cardio vascular damage is going to be in the long term.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by IdEntities on Saturday April 23, 2022 @01:32AM (#31131662)
> For one thing, Covid-caused myocarditis is an order of magnitude or two more frequent than vaccine-caused myocarditis, at all ages.

If only the vaccines would prevent infection, so these risks would be mutually exclusive, instead of cumulative.

> Reinfections are now documented to have happened as closely as 20 days apart !

How soon has an infection been documented after becoming "fully vaccinated"?

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by magicalhippo on Saturday April 23, 2022 @05:39AM (#31132693)
Just a single data point, but a family member in her mid-30s was fully vaccinated (Pfizer) mid-September last year, got Covid in late January and got re-infected a week ago. Both confirmed with PCR tests after positive rapid tests.
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by greenyoda on Saturday April 23, 2022 @01:23AM (#31131618)
Archives of the above ft.com articles, to bypass the paywall:

https://archive.ph/qcO5H

https://archive.ph/AHv1W

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by thomassmith65 on Friday April 22, 2022 @11:27PM (#31131096)
I don't know what to make of a "virtually zero risk"? Is it high enough that one also could say the vaccinated have a "virtually zero risk" of Myocarditis?

It would shed more light to know the delta between unvaccinated and vaccinated for those dead from heart problems vs dead from Covid.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by kadoban on Saturday April 23, 2022 @01:31AM (#31131660)
> Is it high enough that one also could say the vaccinated have a "virtually zero risk" of Myocarditis?

Yes. The risk of myocarditis from covid is higher than this, even if there were zero other effects to consider.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by IdEntities on Saturday April 23, 2022 @01:34AM (#31131677)
But the vaccines don't prevent Covid infection. If the infection rates from Ontario and the UK were to be believed (before the UK stopped publishing the vaccinated vs unvaccinated breakdowns, that is), being vaccinated might even make you more likely to be infected.
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by kadoban on Saturday April 23, 2022 @01:41AM (#31131715)
> being vaccinated might even make you more likely to be infected.

That would certainly seem unlikely. Really the only way that's possible is by vaccinated groups having different behavior. Which is somewhat likely, but then you're not really comparing the effects of the vaccine anymore.

Everything I've seen has shown the obvious, fewer and less serious cases.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by native_samples on Saturday April 23, 2022 @07:00PM (#31139508)
That would certainly seem unlikely

It's actually a proven matter of fact, so it's not really up for debate about whether it's likely or not. It happened already.

The few countries that publish infection rates by vaccine status all show the same thing: the vaccinated get infected with COVID at much higher rates than the unvaccinated and this has been getting worse with time. England, Denmark, New Zealand all show this. There may be other countries by now.

Most countries simply don't publish this basic statistic at all, which is all you need to know about the integrity of public health.

Really the only way that's possible is by vaccinated groups having different behavior

No, negative effectiveness has happened before with vaccines and there are biological pathways via which it can happen. In particular the COVID mRNA vaccines are immunosuppressant. This was known by Pfizer before approval but not mentioned anywhere - it came out during their document dumps. OAS/imprinting is another very likely candidate.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by IdEntities on Saturday April 23, 2022 @01:52AM (#31131764)
> That would certainly seem unlikely. Really the only way that's possible is by vaccinated groups having different behavior.

No, other possibilities which have been observed with other pathogens are Original Antigenic Sin (i.e. perhaps targeting the spike protein from the now-extinct Wuhan strain gets the immune system "stuck in a rut" with a less optimal response) or Antibody Dependent Enhancement. Not to say that these definitely are occurring in the case of SARS-CoV-2, but even Fauci acknowledged the possibility of disease enhancement before the vaccines were rolled out.

A good article on the UK vaccinated/unvaccinated data, which was pulled when it no longer flattered the vaccines: https://igorchudov.substack.com/p/uk-will-hide-vaccinated-ca...

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by renaudg on Saturday April 23, 2022 @01:57AM (#31131792)
To anyone else wondering : that "good article" comes from a notorious antivaxxer : https://twitter.com/ichudov
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by bsaul on Saturday April 23, 2022 @03:44AM (#31132267)
worries about ADE is clearly widespread in scientific community, and the inversion of infection rates, with vaccinated people catching it more than non-vax, has occured everywhere with the most recent variants.

Of course, any scientist name i'll give as a reference will be immediately categorized as "anti-vax" or "fringe and non representative"... Which curiously is still a grave thing, eventhough a lot of the consensus around covid vaccines has been proved incorrect times and times again (with the only remaining truth being that it does protect people at risk from lethal outcome, which is clearly the bare minimum and not the original expected outcome).

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by renaudg on Monday April 25, 2022 @10:06AM (#31154952)
>any scientist name i'll give as a reference will be immediately categorized as "anti-vax" or "fringe and non representative"

That's because they probably are fringe and non representative. And for every Galileo there are 100.000 Dr Wakefield's

> a lot of the consensus around covid vaccines has been proved incorrect times and times again

If that were true it wouldn't be the consensus, by definition.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by native_samples on Saturday April 23, 2022 @07:02PM (#31139523)
You're making a circular argument. Anyone who looks at the UK data showing negative effectiveness cannot avoid being "anti vax" because if vaccines make COVID more prevalent rather than less, then the cost:benefit ratio cannot possibly be positive.

In your construction, actually observing published government statistics and acting rationally on it automatically makes someone a "notorious antivaxxer". It's ideology, not rationality.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by renaudg on Monday April 25, 2022 @10:04AM (#31154912)
No,

What I'm saying is that this guy is a run-of-the-mill antivaxxer, even outside Covid. Check his tweets and blog : he writes fallacious pieces against childhood vaccinations like : https://igorchudov.substack.com/p/florida-vaccine-hesitancy-...

And no, he's not acting rationally. It may have the flavor of it at first glance, but the implications of what he says being true would invalidate large swathes of science. So is he a genius or a crank ? I don't have time to comb through and debunk every single claim (Brandolini's law !) but good old Occam's razor says he's a conspiracist crank who fallaciously massages data until it fits what he set out to prove. That is to say, an ideologue.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by native_samples on Saturday April 30, 2022 @09:34AM (#31215970)
Well, full marks for honesty I guess but aren't you just proving my point?

You haven't read his article or engaged with his argument at all, but he must be a crank because you can't stomach the implications if he was right. A cursory inspection of the first few paragraphs shows that (a) it's about 2021 so definitely not "outside COVID" and (b) it's another example of what I was pointing out: he is looking at government data that looks pretty concerning and reacting to it in a rational way.

Your only argument he's not rational is that "vast swathes" of science would be invalidated if he's right, therefore he must be a crank.

That's not even an argument, is it?

1. Some of the biggest leaps forward in science have come from invalidation and correction of deeply fundamental science. That's why Einstein is famous. The potential to invalidate pre-existing scientific beliefs is pretty much a pre-condition for a study to be interesting.

2. Vaccine efficacy is a tiny sub-area of the overall scientific enterprise. If everything people believed about vaccines was disproven conclusively tomorrow that'd certainly be far less than 0.1% of all scientific knowledge.

3. Your heuristic is totally unable to correct handle or react to groupthink or bad incentives. The entire field of virology claimed that there was no possible way SARS-CoV-2 escaped from a lab and anyone who claimed it could was spreading conspiracy theories. Those same scientists were simultaneously writing private emails saying a lab escape was definitely possible and even looked likely. You were the sort of person who was successfully fooled by their conspiracy, and maybe still are.

Fundamentally, your attitude here is poisonous to the search for truth that defines science to begin with. If you can't be bothered evaluating their arguments then don't express opinions on them.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by michaelmrose on Saturday April 23, 2022 @03:15AM (#31132132)
Just because somewhere a mechanism exists for a vaccine to render a pathogen more dangerous doesn't means that there is any reason to believe that mechanism is meaningfully a factor in this case. The fact that you yourself lack the know how to assess why this is or isn't a risk doesn't mean that everyone is rolling the dice it just means that you are uneducated on the matter.

You give yourself away by your obsession with Fauci whom you always refer to as if he was a mononym like an idiot celebrity. Rarely Dr. Fauci or yet Anthony Fauci. Just fauci. You know a few interesting highly specific terms of art like Original Antigenic Sin which is in stark contrast to your otherwise very shallow understanding of the topic. This is because you collect interesting nonsense like a bird picking up shiny things.

This site doesn't need people who have never created an account with Hacker News before to create one now to spread the same bullshit you folks spread on Facebook. I see folks like yourself all over hacker news in recent years and quite frankly like covid you are a pathogen. Its absolutely impossible to fix the dialogue with you folks because to you these are vital truths that are being ignored. You are for what its worth likely very much in good faith its just that you yourself have been infected. Fix your inputs and maybe you will fix your outputs.

Good Luck.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by kadoban on Saturday April 23, 2022 @05:00AM (#31132558)
> even Fauci acknowledged the possibility of disease enhancement before the vaccines were rolled out.

Sure, but that's something that trials test for before a vaccine gets to the general public.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by IdEntities on Saturday April 23, 2022 @11:00AM (#31134804)
Yep, and the virus has changed a lot since those trials were conducted, and even been subjected to certain evolutionary pressures by mass deployment of the vaccines themselves, which is not something it is possible to study in clinical trials. It's also not really possible to test for OAS because trial participants (at least, those in a highly abbreviated trial like those which were conducted for the COVID vaccines) only encounter one strain of the virus.
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by kadoban on Saturday April 23, 2022 @05:24PM (#31138719)
Has there _ever_ been a vaccine where that happened, where initial trails showed it effective then years later it was worse than nothing?
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by native_samples on Saturday April 23, 2022 @07:09PM (#31139569)
Yes, it's happened quite often unfortunately. And not just years later. Sometimes immediately. Flu vaccine rollouts have shown this effect in the past, as have (failed) HIV vaccines. People who took the Canadian flu vaccine got Swine Flu at a higher rate for example.

The exact cause isn't known because anything that could be perceived as "anti-vaxx" doesn't get funded or honestly researched, even though it's important. But the best bet seems to be a form of imprinting. The immune system prefers to make antibodies that it's made before and does so even if it's exposed to a pathogen different enough to have evolved past those antibodies. For real epidemics this probably doesn't matter much, because they move in waves through the population, but if you repeatedly vaccinate the whole world then you're causing fixation on a long since extinct form of the spike protein. When a mutated virus turns up the body manufactures useless antibodies that don't work rather than trying to develop new ones.

It's actually not even clear that the trials showed positive effectiveness for COVID. They reported it but the way they defined "vaccinated" creates a denominator problem. Their methodology would create the appearance of initially high effectiveness that steadily decays to nothing for anything, including water. Regulators not only didn't notice this but public health agencies adopted the same methodology.

What becomes clear the moment you start learning about this stuff is, we never hear about these problems because any bad news about vaccines is immediately squashed and anyone who points it out gets banned and viciously attacked.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by moistly on Saturday April 23, 2022 @11:56PM (#31141167)
The vaccine was effective against the more dangerous Alpha and Delta variants, where we saw the unvaccinated overwhelming the hospitals.

The vaccine is not effective against the less dangerous Omicron variant, and the hospitals are not overwhelmed.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by kurupt213 on Friday April 22, 2022 @11:29PM (#31131103)
there must be a public record of the number of 16-24 y.o. who died from covid in norway
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by _vertigo on Friday April 22, 2022 @11:15PM (#31131032)
9 to 28 times? I figured “excess events per 100,000” means if the control rate is e.g. 200 events per 100,000 then the observed rate after vaccination was 209 to 228.
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by radford-neal on Friday April 22, 2022 @11:32PM (#31131121)
They give the excess events for vaccinated individuals compared to those not vaccinated, per 100,000 vaccinations. For males age 16 to 24, the excess per 100,000 vaccinations is 5.55 for Pfizer and 18.39 for Moderna. These numbers might be useful if you were comparing the badness of these events with the goodness of whatever you think is the number of Covid infections prevented per 100,000 vaccinations (which obviously depends on the general prevalence of Covid).

They also give a ratio, which could also be interesting, and which you can't deduce from the excess events without knowing the number of events in the reference group.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by kurupt213 on Friday April 22, 2022 @11:28PM (#31131098)
that's an increase of 4.5-14% that is huge, especially when you include that the high risk group has virtually no risk from covid infection.
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by maxerickson on Friday April 22, 2022 @11:58PM (#31131247)
In the US, the rate of Covid deaths in 18-29s is something like 10/100,000.

So if that is virtually no risk, so is 20 cases of myocarditis (that aren't all lethal) per 100,000.

(I used 6100 from https://www.statista.com/statistics/1191568/reported-deaths-... divided by 53 million to get 10/100,00).

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by michaelmrose on Saturday April 23, 2022 @03:18AM (#31132144)
Myocarditis in young people post vaccination rather than being (not all lethal) is virtually never lethal.
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by icegreentea2 on Friday April 22, 2022 @11:39PM (#31131151)
Need data on myocarditis risk (minimally occurance, and ideally a sense of distribution relative severity) of COVID infection in same population.

There's some fuzzy outlines of that data here (https://www.cdc.gov/mmwr/volumes/70/wr/mm7035e5.htm).

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by dham on Friday April 22, 2022 @11:56PM (#31131238)
Yea I'd like to see that data too. I've seen that Myocarditis risk is higher with Covid than vaccine. The main downside I see is you're going to get Covid anyway so you're basically increasing your risk of Myocarditis once with vaccine and then again after catching it.
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by renaudg on Saturday April 23, 2022 @12:40AM (#31131463)
No, because the disease is much less likely to progress as severely once vaccinated, which lowers your risk of Covid-induced myocarditis.

In any case : vaccine-induced myocarditis is almost always benign and resolves without treatment, and while there's been a lot of focus on it in the press and in antivaxxer circles, it's really a footnote in the list of Covid-related health issues.

It's many orders of magnitude less frequent than Long Covid, for example.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by IdEntities on Saturday April 23, 2022 @01:41AM (#31131713)
> the disease is much less likely to progress as severely once vaccinated

There's really no solid data to back this up. The only randomized controlled trials that were ever conducted ended when the EUAs were granted and the placebo groups were immediately vaccinated, long before the Delta variant even existed, let alone Omicron. Everything else is observational studies subject to selection bias and other confounding variables. And even there, the proportion of vaccinated vs unvaccinated deaths from Omicron (where good data is available) does not suggest high levels of protection from the vaccine.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by michaelmrose on Saturday April 23, 2022 @03:29AM (#31132199)
We already know that in a naive host the adaptive immune system takes days to fully engage during which covid can spread far better than in a vaccinated host. This explains why vaccinated hosts are far less likely to end up in the hospital or a morgue than people with identical demographics.

It would be truly remarkable if vastly decreasing the prevalence of the pathogen early on somehow kept you from the hospital but led a far less extensive infection doing just as much damage. Posting solid data here when literally everyone on the forum has sought out such data at one time or another is a waste of everyone's time. If you have succeeded in ignoring it at this point no data is liable to change your mind.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by maxerickson on Friday April 22, 2022 @11:48PM (#31131194)
The better comparison is the total risk after vaccination vs the total risk from infection without vaccination.

Given the infectiousness of the recent variants, it's reasonable to assume very high probability of eventual infection.

(Myocarditis appears to be the more common severe side effect of vaccination, even though it is still quite rare. Hospitalization rates from infection (a reasonable proxy for a severe infection) in the similar age groups are probably higher.)

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by metta2uall on Saturday April 23, 2022 @12:12AM (#31131320)
I don't think it's "virtually zero risk" because there is "long Covid". Regarding myocarditis it seems important to know the prognosis, i.e. how many people quickly recover from myocarditis with apparently no long-term effects?
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by radford-neal on Friday April 22, 2022 @11:24PM (#31131079)
Roughly correct, but a bit high as far as I can see. The papers says risk ratio of 5.31 for Pfizer and 13.83 for Moderna. Not sure where you got 9 and 28.

It does seem that a young male already immune due to having had Covid would be best advised not to get an mRNA vaccine.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by labster on Friday April 22, 2022 @11:28PM (#31131099)
> young male already immune due to having had Covid

Citation needed on the “already immune” bit. So far studies have shown that immunity to the corona wears off, and most people can be reinfected months to a year later.

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by radford-neal on Friday April 22, 2022 @11:36PM (#31131137)
Yeah, they can be infected agains, but that's also true if they've been vaccinated, or both vaccinated and had Covid.

The incremental benefit of a healthy young person getting vaccinated after already having had Covid may be quite small. Plus the incidence of myocarditis in this group (vaccinated after having had Covid) could well be higher than it is in people getting vaccinated who haven't had Covid. (This is plausible, since as seen in this study, the risk is higher for the second shot, when the immune system has already been stimulated before.)

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by kadoban on Saturday April 23, 2022 @01:35AM (#31131682)
It's also very possible that the risks for covid in each possible circumstance are higher than that for the vaccine. Quite likely even.
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by renaudg on Saturday April 23, 2022 @12:42AM (#31131474)
The shortest documented timeframe between infections is actually 20 days !
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by arinlen on Saturday April 23, 2022 @02:39AM (#31131970)
> It does seem that a young male already immune due to having had Covid (...)

There is no such thing as "already immune due to having had COVID".

Unvaccinated individuals were observed to have far higher reinfection rates than vaccinated individuals (over 5-fold higher chances).

https://www.cdc.gov/coronavirus/2019-ncov/your-health/reinfe...

> (...) would be best advised not to get an mRNA vaccine.

This assertion is not only entirely baseless but also completely ignores the fact that a) unvaccinated individuals are a couple orders of magnitude more likely to die from COVID, b) the myocarditis issue pinned to vaccines is benign and transitory, and estimated to be at most less than 5 cases per 100 000 vaccinnees.

https://www.cdc.gov/mmwr/volumes/71/wr/mm7104e2.htm

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by peteradio on Saturday April 23, 2022 @10:19AM (#31134483)
Pretty misleading citation source there, you must be implying the Kentucky study which is infected+vaccinated compared to infected only (not infected to vaccinated as most would read your sentence). You apparently ignore the New York/California study in the same link. All this completely ignores the age factor as well which reduces the absolute risk for youths to essentially negligible.
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by radford-neal on Saturday April 23, 2022 @12:50PM (#31135924)
Yes. Even taking the Kentucky study at face value, the estimate odds ratio (probably similar to relative risk, given reinfection is fairly unlikely) is 2.34 (confidence interval 1.58 to 3.47), not "over 5-fold higher chances".

However, as they say, "...persons who have been vaccinated are possibly less likely to get tested. Therefore, the association of reinfection and lack of vaccination might be overestimated."

Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by michaelmrose on Saturday April 23, 2022 @03:31AM (#31132207)
Why would we take advice from YOU that is contrary to what every nations medical experts are advising?
Re:SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort... by radford-neal on Saturday April 23, 2022 @12:55PM (#31135966)
Well, you shouldn't just take advice from a random person on the internet. But neither should you just take advice from medical experts and official government sources. There is no substitute for thinking.

One thing to think about is that "every nations medical experts" are heavily committed to a narrative that vaccines are good, and hence may be disinclined to admit there are exceptions to this (such as healthy young males who have already had covid). They may think that the vaccine is good for most people, and that they should therefore pretend that it's good for everyone to avoid "confusion"...