Phenethylamines I Have Known and Loved (1991)

Re:Phenethylamines I Have Known and Loved (1991) by dr_dshiv on Thursday March 31, 2022 @05:17AM (#30865281)

He died at 88. Didn’t have heart trouble till 82. Didn’t have dementia till 86. And he took more (types of) drugs than any human ever. So, he was just a little bit more healthy than average, no?

Edit: Thanks for sending me down the 5-HT2b rabbit hole. This was the cause of the Phen-Fen appetite suppressant heart issues. All psychedelics do seem to affect 5-HT2b receptors. I assume this is a dose dependent effect—where a daily high dose of Phen-Fen would be much more dangerous than occasional low weight psychedelic doses. But I appreciate the grounded caution and more research is clearly needed, ideally before I’m 70+.

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Re:Phenethylamines I Have Known and Loved (1991) by anaisbetts on Thursday March 31, 2022 @09:34AM (#30866979)

Indeed, I would not really worry about this given how most people use psychs, but since you mentioned "in your old age", I thought I'd mention some effects that might be more problematic at that age vs. the average person today

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Re:Phenethylamines I Have Known and Loved (1991) by subpixel on Thursday March 31, 2022 @07:29AM (#30866005)

All SSRIs are 5-HT2b agonists, apparently. Do people taking antidepressants have a higher instance of heart disease?

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Re:Phenethylamines I Have Known and Loved (1991) by SpodGaju on Thursday March 31, 2022 @09:08AM (#30866731)

Prozac is an antagonist (not agonist) of the 5HT2C receptor at higher doses. At lower doeses the increased serotonin from SERT inhibition will stimulate 5HT2C.

https://www.pnas.org/doi/pdf/10.1073/pnas.94.5.2036

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Re:Phenethylamines I Have Known and Loved (1991) by caslon on Thursday March 31, 2022 @05:42AM (#30865391)

The average American male dies at 74.2 as of 2020:

https://www.cdc.gov/nchs/products/databriefs/db427.htm

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Re:Phenethylamines I Have Known and Loved (1991) by danielvaughn on Thursday March 31, 2022 @12:48PM (#30869406)

Yeah, at that age it doesn't really matter what kills you - a life that long is something to be celebrated.

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Re:Phenethylamines I Have Known and Loved (1991) by refurb on Thursday March 31, 2022 @08:49AM (#30866574)

All a matter of selectivity. Most drugs affecting the Sheraton in receptions have nanomolar or better selectivity for 5-ht2A, while 1000x less binding at 5-ht2b, which in biological terms is almost inactive at normal dosing.

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Re:Phenethylamines I Have Known and Loved (1991) by tux3 on Thursday March 31, 2022 @11:54AM (#30868605)

Is "Sheraton in receptions" speech to text for serotonin receptors :) ?

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Re:Phenethylamines I Have Known and Loved (1991) by refurb on Thursday March 31, 2022 @11:15PM (#30874827)

Pretty close phonetically!

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