SpodGaju

> So should we ban it then since anyone can get around sanctions using it? Might as well ban encryption then. /s

Encryption has no middle man and is free, and unlike cypto, you are untraceable. So no idea ho you can compare the two

> What would do you suggest then for those who are in countries like Ukraine or Afghanistan then?

A good start would be instigating peace and not war. Stop having the US fight these proxy resource wars by destabilizing them and trying to put in our puppet leaders.

There is a housing bubble across the whole county, people can not be moving everywhere at once.

https://www.cnn.com/2022/03/30/homes/us-housing-market-bubbl...

>> you don’t have to invade country to instigate a war. This is like saying Chris Rock instigated getting hit.

I am in no way condoning the death and suffering the Putin is causing. There is no such thing as a just war.

But really? Comparing "the slap" to all the complexities going on in that region of the world? Is that how simplistic you see life? You think resources have nothing to do with the war in Ukraine? Why was the US pudding for Ukraine too enter NATO? Why is the US involved at all in a country halfway around the world? It means we have an interest there. You know who also has an interest there? Putin. Hence, war. A proxy war.

> Saddam Hussein instigated the Iraq war, didn't he?

No. That happened because the US lied that Saddam had WMDs. (You protested the war in Iraq and you really said that????)

> Did America also instigate Russia's invasion of Georgia, or the flattening of Grozny?

No, Mikheil Saakashvili instigated that when he started working as a stooge for the United States.

> Did we make Putin drop chemical weapons in Syria?

Putin did not drop chemical weapon in Syria.

https://thegrayzone.com/2020/09/29/grayzones-aaron-mate-test...

Biden was not talking about Putins wife. He is working with NATO and Oil Companies to secure resources in a world where they are becoming harder to come by. I blame them BOTH for the war. I Balme the BOTH for lying and being psychopaths. I blame the both for the suffering of the Ukrainian PEOPLE. I blame them ALL for not trying more to work for peace.

Wy have you not brought up the war against the Donbas people in Ukraine? Why have you not brought up the war against the Palestinians? Or the war agains Yemeni? Do you think the CIA does not play a role in making countries unstable? Really?

You simply the war in Ukraine because it helps you cope with a complicated world.

Can you imagine what the US would do if Russia was as involved in Mexico and Canada as much as we are in Ukraine and Georgia? OF course to you, that would be a just war.

The article was not about Afghanistan.

But we can talk about how the U.S. is creating the sanctions in Afghanistan. And we can also talk about how Russia is using Crypto to get around sanctions.

All crypto does is make money for the gatekeepers of crypto and profit off of war, sanction, and fear. Crypto solves zero problems, it only profits off of the problems governments create.

I know that. There’s also zero evidence that any of the drugs that these people have taken have extended their lives. They’re absolutely zero studies that show that these compounds are either safe or dangerous. Anyone saying that they’re either has a bias.

And there is no evidence that McKenna’s drug use did not cause his brain cancer. Absence of evidence is not evidence of absence. The best we can say is that we do not know.

Misleading title. Headline is

“Ukraine’s Crypto Banker Describes How War Is Changing His Life”

Crypto is saving zero lives in Ukraine and all this guy is doing is profiting from war and fear.

I would advise you to look into how to help your body make Phenethylamine on its own. You probably have a higher need for P5P (B6) than most people.

The enzyme, DDC, needed to make endogenous PEA needs adequate P5P to function.

https://www.uniprot.org/uniprot/P20711

https://pubmed.ncbi.nlm.nih.gov/1729407/

Decarboxylation of phenylalanine by aromatic L-amino acid decarboxylase (AADC) is the rate-limiting step in the synthesis of 2-phenylethylamine (PE), a putative modulator of dopamine transmission.

Terrance McKenna died at 53.

Dose is probably important in all this but it’s hard to say with such a small, probably biased, sample size.

Prozac is an antagonist (not agonist) of the 5HT2C receptor at higher doses. At lower doeses the increased serotonin from SERT inhibition will stimulate 5HT2C.

https://www.pnas.org/doi/pdf/10.1073/pnas.94.5.2036

OK, wait, let me call at my pharmaceutical buddies and have them do a study that shows that the New drug they wanna make billions of dollars from works just like Prozac but faster. I’ll get back to you in a minute.

The fact that people are even slightly amazed at an amphetamine will make people happier is amazing to me. Don’t you’ll realize you’re substituting Street dealers for dealers in suits?

You want to see funny? You said:

> One of the main theories on the action of MDMA involves the sudden serotonin release inhibiting the amygdala and thus reducing fear response. Prozac certainly does not do this.

{cough}

Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832021/

Chronic fluoxetine prevents fear memory generalization and enhances subsequent extinction by remodeling hippocampal dendritic spines and slowing down systems consolidation

https://www.nature.com/articles/s41398-019-0371-3

Serotonin-2C receptors in the basolateral nucleus of the amygdala mediate the anxiogenic effect of acute imipramine and fluoxetine administration

https://academic.oup.com/ijnp/article/15/3/389/720875?login=...

You read some articles. That is not enough. You are being duped by more pharmaceutical company propaganda.

Have you ever ask yourself why they don’t investigate the reason people are not producing enough serotonin? Or white people lack serotonin?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337390/

you know I can hold two thoughts in my head at the same time. I can be appreciative of taxes and the system that helps support others who are in need, and I can at the same time advocate for a system that doesn’t create peoples destitution.

I know, change is hard.

So may be the problem is you never understood Anarchism. Because what’s happening in Portland is nothing close to Anarchism. It’s anarchy, with a small a. Now I guess you would call yourself an anarcho capitalist? Please don’t get me started….

You got greedy, that’s all that happened. It’s nothing complicated. You LARPed an anarchist when you were a kid, you traveled around, then somehow made some money, and you were able to end up buying a house in Portland. And now, the very system you used to make that money is destroying Portland and you’re complaining about the people? I get complaining about the government, but you’re putting all this on the people? Do you think people are kids wanna grow up to be addicted to drugs?

Portland didn’t fail because the culture changed, Portland changed because of housing speculation and housing investments and a housing bubble. Portland’s failing because of capitalism.

And this is the reason why I said look in the mirror.

And you don’t have to invade country to instigate a war.

I meant I don’t care what people think of how I write or speak. I don’t care about being nice. My frustration stems from me caring about people. And caring about people who are being mistreated by doctors.

Yes, it works more quickly. That’s the only difference. And it is more like the SNRIs, like cymbalta with some effect or encouraging the release of catecholamines.

But the effect is the same, more neurotransmitters in the synaptic cleft.

People abuse Prozac as well if that given you a clue on their similarities.

https://pubmed.ncbi.nlm.nih.gov/8093133/

https://ajp.psychiatryonline.org/doi/abs/10.1176/ajp.150.12....

I was nice for 25 years. It didn’t change minds. Being nice doesn’t change their mind and neither does being angry. I’m just frustrated and I don’t care anymore. There’s too much money involved in all this for people to change their minds.

This information about the effectiveness of Prozac and most anti-depressants has been out for over 12 years now. What good is it for me to site this information? No one cares. And let’s see if more people started caring, don’t you think the interest, the money interest in these drugs will come back full force?

And whatever about references, references don’t change peoples minds either. Did you just see what happen with Covid? You can show people proof and fax all you want but everyone is in their own individual cult now.

Just in case you all still think they are on the right track with these methods of treating mood disorders, look at the data you are basing your claims on.

https://www.scientificamerican.com/article/many-antidepressa...

"Meta-analyses by industry employees were 22 times less likely to have negative statements about a drug than those run by unaffiliated researchers. The rate of bias in the results is similar to a 2006 study examining industry impact on clinical trials of psychiatric medications, which found that industry-sponsored trials reported favorable outcomes 78 per cent of the time, compared with 48 percent in independently funded trials."

And if you think MDMA treatment is not about money you are worse than ignorant:

https://www.fastcompany.com/90720911/mindstate-psychedelics

Venture capital firms have taken notice—pouring money into startups developing psychedelic treatments for everything from PTSD to smoking cessation. A January analysis by Business Insider identified 11 venture capital firms (most of them founded in the past three years) that have collectively invested roughly $140 million in the psychedelics category. Funding accelerated after psychedelic startup Compass Pathways raised $146 million in its September 2020 initial public offering and an additional $144 million in a secondary offering in April 2021.

I do not care if people take me seriously, I care if they take the facts seriously. I know I know more about psychopharmacology than the majority of people on HN. I do not need to prove that to anyone.

I have been talking nicely about this stuff for years, it does not matter because the corporate propaganda for these meds is too powerful, so what you hear is a normal human response; frustration. I do not think most people are stupid, I think they are ignorant.

This method of treating symptoms of mood disorders is at best, harmful.

> No amount of localised niceness is going to undo decades of absolutely brutal culture.

Well said.

Were his side affects placebo as well?

> There is a biological marker for the need of many drugs too

Not for psychiatric drugs, which is my only point. I am not against pharmaceuticals.

FDR saved capitalism. There is no fixing capitalism since exploitation is necessary for its existence.

Sorry man, I know several people who were injured by some of these meds. It is not talked about enough when they prescribe them.

Regarding Genomind, these are really limited in how much they will help. They test a limited amount of genes that "might" change drug efficacy. Even taking into account the CYP genetics, if someone is anemic these enzymes will function more slowly so emvironment will trump genetics.

https://jamanetwork.com/journals/jama/article-abstract/19539...

"At this time, DTC advertisements are inappropriate, given the public's limited sophistication regarding genetics and the lack of comprehensive premarket review of tests or oversight of advertisement content."

And from the really the only study claiming that Genomind is effective, from their website:

https://genomind.com/the-science/

Citation: Perlis RH, et al. Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study. Depression & Anxiety. 2018;35(10):946-952. doi:10.1002/da.22742

"Dr. Imbens reports personal fees from Genomind, for experimental design related to the submitted work, and personal fees from Eli Lilly, outside the submitted work."

And if you look through all of those studies you will find they were funded by Genomind.

Truth! Telling people like me to "face their demons" when they pushed me into homelessness but the demons still live with me in my van.

I am not saying this to be mean, but people who have encourage these approaches do not have a mood disorder. They are sad people with sad lives.

Why do you think I wrote that?

If you have never taken these medication you have never known what it is like to try to stop them. Heroin could be considered a life saving medicine in the same vein.

Prozac artificially increases serotonin as as a result your serotonin receptor density changes. So trying to stop the drug, not only do you end up with all these horrible side effect, but your depression will be much worse until your receptor density normalizes again.

There is a biological marker for the need of insulin. There is no such thing when it comes to prozac.

Keep trying people.

They were different. 6% different. That is a big raise for any income.

What absolute? That MDMA increases serotonin in the synaptic cleft just like prozac?

Also, these "progressives" have never tried to address the flaws of capitalism in any meaningful way. FDR knew what to do to "save capitalism".

And organized crime and poverty climb on the backs of each other. To blame one or the other is simplistic.

> Bit of carrot and stick.

The subtle psychology exposed in this sentence. You say you are an anarchist but here you are wanting to control others. You think you are smarter than these suffering people and will treat them like dogs with a treat to get them to do what you want.

> It's about handling their problems, as I have had to handle my own.

Again, you remain the individual. You think if everyone "lived like you" they would be fine. Not everyone can handle their own problems and some peoples problems are bigger and more complicated than yours were.

> So go ahead and shit on the people who were out in the streets protesting

I protested the Iraq war as well, so no idea what you are going on about here. I know it was useless because no one is protesting the U.S. involvement in the war in Ukraine. Everything happening now, including all the propaganda, is the same as it was before the Iraq war.

If you want to know why Portland is failing, look in the mirror.

> I can't spend my life taking care of people who refuse to take care of themselves.

This is how a society collapses, when people think they know who "refuses" to take care of themselves and who simply cannot.