Re:The Uselessness of Phenylephrine
by netizen-936824 on Thursday March 31, 2022 @06:40AM
(#30865704)
>The United States FDA clearly states “severe liver damage may occur if you take more than 4000 mg of acetaminophen in 24 hours.”
>There is no question that the upper threshold on the maximum daily allowed dose of APAP has been the subject of controversy.
The difference is you can build a tolerance to opioids, so the LD of hydrocodone in an addict (or even just someone using for an extended period medically) will be FAR higher than in an opiod-naive person.
Opioids kill via respiratory depression, not by destroying your organs.
According to this [1] the minimum single dose toxicity for APAP is more like 7.5 to 12 grams. Finding a value for a lethal hydrocodone dose is more difficult, but I did see 90 mg mentioned.
For the dose of Vicodin you specified, 90mg of hydrocodone would correspond to 9 grams of APAP. So it's a race that it looks like either one could win.
[1] https://www.uspharmacist.com/article/acetaminophen-intoxicat...