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Re:What the Omicron wave is revealing about human immunity by Mikeb85 on Thursday February 03, 2022 @10:22AM (#30193555)
> T-cell immunity was considered borderline conspiracy theory until recently.

It's funny how the pandemic caused people to toss our decades of understandings of viruses out the window because it was politically expedient.

It's always been known that if your immune system allows you to recover from a virus, you will have some level of lasting immunity.

Re:What the Omicron wave is revealing about human immunity by spookthesunset on Thursday February 03, 2022 @11:56AM (#30194936)
Calling Covid a "novel" virus was a mistake. Technically it's true but that didn't mean we needed to toss out everything we learned about viruses and start from first principles. Even from way back in March of 2020 even the most basic things we knew about viruses felt controversial. People were seriously thinking you could catch and transmit covid after like 3 months or something--like you'd just constantly get re-infected over and over again. And people flipping out about outdoor transmission... like when has catching a virus outside ever been a real thing? Everything we knew about the subject had to be re-proven.

It was and still is completely crazy.

Re:What the Omicron wave is revealing about human immunity by rhino369 on Thursday February 03, 2022 @03:15PM (#30198147)
Some of the problems with our response is actually based on the opposite issue, our first response impulses were to treat it like a novel flu strain. So we re-ran the H1N1 playbook. The flu was believed to be mostly spread by droplets/surface contact and not airborne, so they assumed covid was too.

The issues you are describing is more the problem that health officials shift the burden of proof depending which assumptions or policies they want to make. Any facts that counter their policies have to be proven by significant evidence. And they often wouldn't look too hard. A fact that supports their conclusion can be assumed until proven otherwise.

Re:What the Omicron wave is revealing about human immunity by tremon on Thursday February 03, 2022 @04:56PM (#30199531)
Calling Covid a "novel" virus was a mistake

It was called a novel virus to indicate that no person already had (acquired) immunity against it. What inference you make from the word "novel" is on you, not on the rest of the world.

Re:What the Omicron wave is revealing about human immunity by nradov on Thursday February 03, 2022 @10:16PM (#30202388)
That remains unclear. Some research indicates that exposure to other coronaviruses might have given some people a limited degree of acquired immunity against SARS-CoV-2.

https://doi.org/10.1016/j.ijid.2021.07.015

https://doi.org/10.1016/j.ebiom.2022.103831

Re:What the Omicron wave is revealing about human immunity by beebmam on Thursday February 03, 2022 @12:07PM (#30195107)
Many people got Delta and then Omicron even 1 month later. Kai Ryssdal from NPR for example, and one of my friends did too.

So this isn't crazy; it literally happens to many respiratory viruses. Viruses mutate

Re:What the Omicron wave is revealing about human immunity by spookthesunset on Thursday February 03, 2022 @12:30PM (#30195538)
Yup. But like you said many respiratory viruses do that. Does that make the flu virus many of us catch every year novel? How about the common cold? Is each specific virus also novel?

Why did we decide to throw out everything we knew about viruses for SARS-CoV-2? It's like society discovered "OMG I could catch a virus and die!". Not realizing that virtually nothing was new about SARS-CoV-2. It's just a respiratory virus like any other we've had passed through millions of generations of living beings. Oddly enough the "broader human species" managed to survive and thrive through all of them.

Re:What the Omicron wave is revealing about human immunity by enchiridion on Thursday February 03, 2022 @12:11PM (#30195175)
I always wondered how people claim that. Did they have two pcr tests or something else telling them what variant they had?
Re:What the Omicron wave is revealing about human immunity by ddek on Thursday February 03, 2022 @12:59PM (#30196027)
I had delta in late October and omicron in early December. I was PCR positive for delta, although I had a mild case. I wasn't allowed to take a PCR test for the December infection, because it was too soon after my delta test and my symptoms were very mild. I did test positive multiple times on LFT, my symptoms matched the 'ultramild' omicron (scratchy throat, slight cough, lower back pain). The day I tested positive for omicron was 4 days after my friends had gathered in a pub, of the 30 of us in attendance 27 tested positive on the same day. The group chat was wild. Some of those that got PCR's were informed they had omicron.
Re:What the Omicron wave is revealing about human immunity by rsynnott on Thursday February 03, 2022 @01:31PM (#30196527)
Most PCR tests will discriminate between (B.1) Omicron and things which are not B.1 Omicron, so it's feasible to know this. I mean, strictly speaking all you'd know is that you had B.1 Omicron plus something else, but if you had the non-B.1 Omicron one in October, then in most parts of the world you'd be pretty safe in assuming that was Delta.
Re:What the Omicron wave is revealing about human immunity by pessimizer on Thursday February 03, 2022 @02:29PM (#30197488)
> Calling Covid a "novel" virus was a mistake.

I don't remember anyone ever doing that. I remember them calling it a novel coronavirus, because it is a new coronavirus, at least to us.

Re:What the Omicron wave is revealing about human immunity by notahacker on Thursday February 03, 2022 @03:11PM (#30198096)
We didn't have to toss out everything we learned about viruses and start from first principles, but certainly people's irritation with COVID restrictions seems to have provoked people to ignore decades of research to the contrary to make bizarre assertions like you can't catch viruses outside or get reinfected (ironically the early scientific and mainstream speculation about if COVID would be different was mostly taking the optimistic tack that COVID might be less likely to cause reinfection than respiratory viruses endemic in the human population like flu...)

Same goes for the T-cell immunity really: it was pretty much a given that the body's normal immune processes still applied to coronavirus, but what was novel was the unscientific community insisting that they couldn't possibly be reinfected and a course of vaccines couldn't possibly give them any benefit to their immune system after they'd been infected (someone should tell all the old people who get flu shots every year!)

Re:What the Omicron wave is revealing about human immunity by Thiez on Thursday February 03, 2022 @05:02PM (#30199637)
> someone should tell all the old people who get flu shots every year

What we call the flu is not a single virus that comes once a year. It's different types of virusses each time, and the flu vaccine targets the most likely candidates of that year. So no, you don't generally get REinfected with the flu, because it's a different virus. Some of the virusses that we consider 'the flu' are actually corona virusses, and perhaps covid19 will join that list as it becomes endemic.

Re:What the Omicron wave is revealing about human immunity by nradov on Thursday February 03, 2022 @10:29PM (#30202490)
No one who is familiar with viruses considers other human coronaviruses to be "the flu". They aren't even in the same phylum! All influenza viruses are Negarnaviricota whereas all coronaviruses including SARS-CoV-2 are Pisuviricota.

There are four other endemic human coronaviruses which typically cause common cold symptoms. Those symptoms are clinically distinct from the flu in most cases.

https://doi.org/10.1016/S0262-4079(20)30862-9

Re:What the Omicron wave is revealing about human immunity by notahacker on Thursday February 03, 2022 @05:14PM (#30199772)
What we call the flu also includes a wide variety of viral illnesses better known as the common cold, which includes some coronaviruses - the flu shots offer no protection against most of these different viruses

What medical practitioners call the flu is a small subset of influenza viruses common in humans, each with a high potential for reinfection, including reinfections within a year (as well as constantly evolving variant strains, just like COVID)

Re:What the Omicron wave is revealing about human immunity by clairity on Thursday February 03, 2022 @12:57PM (#30195994)
'novel' is a perfectly cromulent term for covid-19. what's not cromulent is the unreasonable and extraneous reaction to a 'new' cold virus. every new virus will have outsized effect until we settle into steady-state (which depends on the dynamics of the virus).

what leadership needed to do was identify the dynamic threat--mainly to the elderly & immune deficient--and mitigate for them, not run around screaming like discombobulated chickens promoting throw-everything-against-the-wall safetyism. we could have had highly targeted mitigations and minimal disruption to our lives; instead, we got incessant debates over useless masking, lockdowns, and vaccine mandates.

even including the elderly and immune deficient, over 99% of people get covid and recover just fine. this isn't the black plague by any stretch of the imagination.

Re:What the Omicron wave is revealing about human immunity by wolverine876 on Thursday February 03, 2022 @02:43PM (#30197710)
> every new virus will have outsized effect until we settle into steady-state

No, this one killed more people than anything in US history, more than wars, prior pan-/epidemics, etc. In my lifetime, no 'new virus' has had any sort of similar effect at all, by orders of magnitude.

Re:What the Omicron wave is revealing about human immunity by clairity on Thursday February 03, 2022 @03:31PM (#30198370)
the flu kills ~36K/year, so if you're ~22+ year old american, then the influenza virus has killed more people in your lifetime than covid.

we don't know yet what steady-state looks like, but note that medical/epidemiological organizations don't generally keep death statistics on colds (caused by rhinoviruses, coronaviruses, etc.) because they're not a significant number. colds can be a contributing factor in death for folks with deficient immune systems, just as it is with covid, but is generally not the sole cause.

again, >99% survive covid just fine. for people with multiple co-morbidities, it's much more serious (whole percentage death rates), but that's because they're teetering on the brink already, and covid (or any number of respiratory diseases, really) can push them over the edge. our mitigations should focus on the aged and unhealthy, not everyone (especially not children).

Re:What the Omicron wave is revealing about human immunity by wolverine876 on Thursday February 03, 2022 @10:42PM (#30202590)
> >99% survive covid just fine

That's not a good survival rate, though the number sounds big.

> it's much more serious (whole percentage death rates), but that's because they're teetering on the brink already, and covid (or any number of respiratory diseases, really) can push them over the edge. our mitigations should focus on the aged and unhealthy, not everyone (especially not children).

The people at risk are not nearly all "teetering on the brink", nor have they died at this astounding rate from other causes. We could save their lives.

People are dying; and we can save them, and we could have saved many more. Blood is on the hands of the those who stood in the way.

Re:What the Omicron wave is revealing about human immunity by clairity on Friday February 04, 2022 @01:50PM (#30211200)
99+% is a big number no matter how you try to slice it. people on the brink should assess and mitigate their own risk, with reliable, honest information and help where needed, not paternalistic overreach. people are dying, full stop, every single day, day in and day out. why weren't you so concerned about the millions who have been dying all along? why weren't you sounding the alarm like this about the flu that has killed more people in your lifetime than covid (which likely always will be the case)? let go of the mediopolitical propaganda and move on.
Re:What the Omicron wave is revealing about human immunity by api on Thursday February 03, 2022 @10:27AM (#30193614)
One of the worst things about Donald Trump was that if he or anyone adjacent to him actually said anything good, it immediately became toxic. They did do so every once in a while, but it was so throughly mixed with shit that it became contaminated.

If Trump said the sky was blue, suddenly it would have to be red and if you were a red sky denier you were a racist. We are still dealing with the echoes of this and will be for at least five years.

This is why having a super-polarizing troll in office is inherently bad for society. I think that's true regardless of their stripes. An obnoxious troll from the "left" would be no better in this particular regard.

There's a reason high office leaders need to carry themselves professionally. Class (of the behavioral sort) is not some old fogie cultural superstition. Leaders that carry themselves like Trump actually damage the cognition of the people in their society.

Re:What the Omicron wave is revealing about human immunity by Veen on Thursday February 03, 2022 @10:39AM (#30193786)
There's truth in the idea that Trump supporting an idea made it toxic even if it was a good idea, but it didn't happen in a vacuum. It happened because the anti-Trump media attacked everything Trump said, whether it was sensible or not. They could have taken a neutral perspective and assessed his speech on its merits, but they did not and they bear some repsonsibility for that.

(To be clear: I'm not a Trump supporter and I think that when he was right it was by accident rather than design. However, many media organizations shamed themselves by embracing partisanship and abandoning even the pretence of neutrality).

Re:What the Omicron wave is revealing about human immunity by kenjackson on Thursday February 03, 2022 @11:43AM (#30194737)
Are there a lot of examples of this? In general when Trump said the right thing it seems like the media didn't go too far overboard. The most obvious example was about vaccination itself. While people were worried that he would push out a vaccine that wasn't ready, people were on board with vaccination.

That said, I do think that Trump's brand was largely about division on social issues. So to that extent he often put at the forefront of his narratives positions that forced you to take a side. E.g., should Kaepernick be fired or not. Etc...

Re:What the Omicron wave is revealing about human immunity by naasking on Thursday February 03, 2022 @12:09PM (#30195146)
> In general when Trump said the right thing it seems like the media didn't go too far overboard.

I'd say those aren't the problem so much as the borderline cases where there are true and untrue interpretations of a certain statement, but of course they ran with the most uncharitable possible interpretation because they're convinced Trump is a ruthless dictator in the making.

Re:What the Omicron wave is revealing about human immunity by brimble on Thursday February 03, 2022 @12:48PM (#30195847)
I think media treatment of him was really weird. Some things were exaggerated, but something like suggesting, during the '16 campaign, in a plainly favorable tone, that his supporters might assassinate his opponent if she won, should have been the only thing anyone wanted to ask him or his proxies about until he was hounded out of public life. Instead it was dropped surprisingly quickly.
Re:What the Omicron wave is revealing about human immunity by kenjackson on Thursday February 03, 2022 @01:09PM (#30196173)
I think the media treatment was fair and evenhanded. I think what has changed with the media is that nothing sticks for very long. As you note, what might have been a big story in the past has a really short news cycle now. What was remarkable about Trump was the shear volume of stories -- each lasted for days, but was then followed up immediately (or concurrently) with another. Even Jan 6 is having trouble sticking in the news.

I think this was one of the issues that the Republicans ran into with the election. They thought that certain stories about Biden would stick and last. They missed that none of these stories last any more. You need a huge volume of stories to paint a narrative over a long period of time.

Someone else mentioned the uncharitable interpretations of things he said. That was earned over years of such statements. It wasn't a new isolated incident.

Re:What the Omicron wave is revealing about human immunity by brimble on Thursday February 03, 2022 @02:19PM (#30197324)
> Someone else mentioned the uncharitable interpretations of things he said. That was earned over years of such statements. It wasn't a new isolated incident.

You're right to such a degree that I distinctly remember my first impression of him being formed by Rush Limbaugh (my dad was a listener) making fun of what a dishonest, sleazy joke of a human being Trump was. Must have been some time in the 90s. His reputation was decades in the making, and at one time that take on him was practically universal. The transformation was fascinating to watch.

Re:What the Omicron wave is revealing about human immunity by brimble on Thursday February 03, 2022 @03:15PM (#30198144)
(can't edit, but not sure if the DV was over disbelief or for some other reason—if the latter, cool, no problem, I take no issue with whatever your reason was; if the former, it's on YouTube and it's exactly what I've said it is, though on review technically he may merely have been suggesting that the "2nd amendment people" [as he put it] might shoot Supreme Court justices... so, you know, not exactly better. It's not clear which of those—or, maybe both—were what he had in mind when he said it.)
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Re:What the Omicron wave is revealing about human immunity by kenjackson on Thursday February 03, 2022 @01:03PM (#30196096)
Those aren't examples of the media gaslighting people. Those are about the CDC and FDA saying they aren't effective (or not proven effective). You're conflating the media with scientific advisory boards -- and notably those under Trump's own watch at the time.

Media gas lighting would be if the CDC/FDA/etc said that Ivermectin was effective and the media saying it wasn't or not reporting on it.

Re:What the Omicron wave is revealing about human immunity by steveylang on Thursday February 03, 2022 @01:30PM (#30196521)
The media gaslighting part is continuing to call ivermectin a horse medicine to disparage it, when it is also approved as anti-parasite medication for humans (if not for COVID.)
Re:What the Omicron wave is revealing about human immunity by notahacker on Thursday February 03, 2022 @03:24PM (#30198287)
People were ordering from livestock suppliers in preparations designed to treat horse conditions, to the extent stockists started running out and started demanding people provide evidence they actually owned a horse to buy it. I mean, dog food is just meat from the same animals humans eat, but it's still a news story if people decide they'd rather eat Pedigree Chum than take nutrition advice from doctors.
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Re:What the Omicron wave is revealing about human immunity by kenjackson on Thursday February 03, 2022 @02:12PM (#30197206)
This is an example of when people say, "I'll do my own research" I often roll my eyes. First, about the site you gave, here's what BMJ has to say about this site:

"Different websites (such as https://ivmmeta.com/, https://c19ivermectin.com/, https://tratamientotemprano.org/estudios-ivermectina/, among others) have conducted meta-analyses with ivermectin studies, showing unpublished colourful forest plots which rapidly gained public acknowledgement and were disseminated via social media, without following any methodological or report guidelines. These websites do not include protocol registration with methods, search strategies, inclusion criteria, quality assessment of the included studies nor the certainty of the evidence of the pooled estimates. Prospective registration of systematic reviews with or without meta-analysis protocols is a key feature for providing transparency in the review process and ensuring protection against reporting biases, by revealing differences between the methods or outcomes reported in the published review and those planned in the registered protocol. These websites show pooled estimates suggesting significant benefits with ivermectin, which has resulted in confusion for clinicians, patients and even decision-makers. This is usually a problem when performing meta-analyses which are not based in rigorous systematic reviews, often leading to spread spurious or fallacious findings.36"

Furthermore, in good faith I went and randomly looked at one of the studies cited that sourced a reasonable journal: https://onlinelibrary.wiley.com/doi/10.1002/jmv.27469

The c19ivermectin site misrepresents the results from the study. To quote the actual study: "However, a mortality benefit was not seen with ivermectin treatment before and after PSM (p values = 0.07 and 0.11, respectively). ICU admission, and intubation rate were not significantly different between the groups (p = 0.49, and p = 1.0, respectively). No differences were found between groups regarding the length of hospital stay, ICU admission, intubation rate, and in-hospital mortality."

Additionally the study notes: "The ivermectin group was more likely to have bacterial pneumonia complications compared to the control group (43% vs. 23%, p = 0.02). Eight patients had a pulmonary embolism or deep vein thrombosis in the ivermectin group, and the ivermectin group more frequently received therapeutic anticoagulation therapy than the control group. In addition, 13 patients had acute kidney injury in the ivermectin group."

The website you provided has a very biased take on just the one study I looked at. It's hard for me to take it seriously as an unbiased meta-analysis of ivermectin.

Re:What the Omicron wave is revealing about human immunity by jamesblonde on Thursday February 03, 2022 @03:15PM (#30198148)
This is cherry picking at its worst. I found one bad study from 78! studies. Therefore, I will ignore all studies. Even worse, none of your double blind RCTs are multi-site western studies. So, I will ignore all of them. Do you know what? After 2 years. 2 years, there has not been even one WESTERN double blind RCT of Ivermectin for Covid that has reported its data. Not one. There are 3 ongoing - Oxford (paused now, because they cannot get supply - what a joke), Covid-OUT (reporting in maybe 2 months), and NIH (reporting in 2023). The Together trial finished in August, but they are still sitting on the data - why?

Besides those trials, there are 87! studies from lots of countries. One really good observational study with ~200k participants (120k in the treatment group) from Itaj Brazil for IVM as prophylaxis. Results for propensity matched data were hospitalizations down by 85%, and for non propensity matched 50%. But nobody has written about it. The same goes for Fluvoxamine, which has great data. As does Melatonin and Curcumin. Lots of treatment and prophylaxis options out there.

And yes, i am vaxxed. But I despair at this notion that it is vax or treatment. I chose both.

Reference:

https://www.cureus.com/articles/82162-ivermectin-prophylaxis...

Re:What the Omicron wave is revealing about human immunity by the_why_of_y on Thursday February 03, 2022 @04:51PM (#30199467)
Here somebody took the time to look at 30 of these studies. It is an interesting read.

https://astralcodexten.substack.com/p/ivermectin-much-more-t...

Re:What the Omicron wave is revealing about human immunity by jamesblonde on Thursday February 03, 2022 @05:02PM (#30199631)
That's a well-written hit piece by Scott Alexander. This isn't big tobacco of old who transparently lie. This article gives short biased summaries of all papers, and leaves out all the good results of many papers. Even well run studies, like Chaccour, that shown stat sign reduction in cough and ansomnia in only N=24, he spins as a negative result. And the Italian study that just barely misses stat sig reduction in viral load - well he doesn't tell you that, does he?

Scott also believes the benefit from IVM is because of worm reduction. The Ijatai study with >120k subjects is an area of Brazil with no worms, proving that is transparent nonsense.

Re:What the Omicron wave is revealing about human immunity by kenjackson on Thursday February 03, 2022 @03:54PM (#30198671)
I randomly picked the first study of a journal id heard of. I’m not going to read all 78. It’s not cherry picking when you do that.
Re:What the Omicron wave is revealing about human immunity by jamesblonde on Thursday February 03, 2022 @04:51PM (#30199474)
Irrespective of whether it's random or cherry picked, you can't discount a mountain of evidence from N=1. That is the playbook Big Pharma have succeeded with so far. Find one trial with evidence of fraud (El-Gazaar DBRCT) and then discount all other clinical trials on IVM for Covid. The media bought it hook, line, and sinker.
Re:What the Omicron wave is revealing about human immunity by kenjackson on Thursday February 03, 2022 @05:12PM (#30199749)
I absolutely can discount a mountain of evidence from N=1. If you bring me 10 candidates for a job and say they can all type 100 WPM and I say, "OK, give me that guy in the middle" and give him a typing test and he types 20 WPM, I'm discounting the rest of the candidates because I no longer trust the source.

Furthermore, the issue isn't the study. It's how they misrepresented the results of the study. Another example, it would be like if you give me a paper and I go to the middle of the paper and it says, "Nazi's saved millions of Jews from the rein of terror of the Hawaiians" -- I'm going to discount the paper because I think the editorializing is misleading. I don't need to read the rest of the paper -- unless you tell me that the section I read was meant to be satire.

This is why credibility matters. If that site was Nature and I looked at one study and there was something wrong with it I might be inclined to look at a few more randomly. But given that people have a finite amount of time, when you present something it better be accurate. And when it is accurate, you'll gain credibility. But if the first thing I look at is misleading -- I don't have a lot of patience to wade through data ... especially when other sources also say that you're representations are biased.

Re:What the Omicron wave is revealing about human immunity by jamesblonde on Thursday February 03, 2022 @05:39PM (#30200047)
The reason why many of the studies are poorly written and have methodological limitations is that many are done by clinicians in 2nd world countries. Not one large DBRCT from the west has reported on IVM for Covid yet. Let that sink in.
Re:What the Omicron wave is revealing about human immunity by jamesblonde on Thursday February 03, 2022 @05:36PM (#30200016)
If you don't like ivmmeta.com, have a look at this published meta analysis of ivermectin for covid. It reaches the same conclusions. And yes, there is also a cochrane meta analysis that cuts out all by 9 DBRCTs (ha!), still is positive, but not stat-sig.

https://journals.lww.com/americantherapeutics/fulltext/2021/...

Re:What the Omicron wave is revealing about human immunity by jamesblonde on Thursday February 03, 2022 @05:09PM (#30199720)
Way to go mods with the censorship, hiding these comments. History will not be on your side.
Re:What the Omicron wave is revealing about human immunity by nonameiguess on Thursday February 03, 2022 @11:29AM (#30194502)
This is kind of arguing in circles, though. A big part of the reason media is so hard on Trump is that he is classless and they were embarrassed he was their president. It's not like his public image was any better in 1990 well before he ever openly declared political ambitions and decided he was a Republican. He'd been a sideshow clown for decades. Arguably, the ridiculous level of polarization we already had is the only reason he got to where he is. Even most Republicans were embarrassed of him until he won the nomination and they rallied to the only option left that wasn't a Democrat. But thanks to having way too many candidates in the primary, he didn't need the support of "most" Republicans. He just needed more than Ted Cruz and Jeb Bush.
Re:What the Omicron wave is revealing about human immunity by anshorei on Thursday February 03, 2022 @10:45AM (#30193873)
As someone who considers themselves an outside onlooker, I disagree. Trump allowed all of the tribal people to out themselves. It's made it a lot easier to find people who stick to their principles and praised/criticized him where appropriate.
Re:What the Omicron wave is revealing about human immunity by mynameishere on Thursday February 03, 2022 @10:47AM (#30193888)
You just described one of the many problems with the media and then blamed it on Donald Trump. Why couldn't you have said "One of the problems with the media is..."
Re:What the Omicron wave is revealing about human immunity by wolverine876 on Thursday February 03, 2022 @02:44PM (#30197729)
I don't recall that happening. Can you give examples? That sounds like Trump's behavior, not others.
Re:What the Omicron wave is revealing about human immunity by kerneloftruth on Thursday February 03, 2022 @10:46AM (#30193883)

   One of the worst things about Donald Trump was that if he or anyone adjacent to him actually said anything good, it immediately became toxic.
That wasn't the worst thing about trump.... it's the worst thing about the media coverage of him. You're blaming him for how media covered him.
Re:What the Omicron wave is revealing about human immunity by hdjjhhvvhga on Thursday February 03, 2022 @10:53AM (#30193971)
Why not both? Trump behaved in a provocative way for a reason - it's not like he was a poor misunderstood thing and the media picked up on him for no reason.
Re:What the Omicron wave is revealing about human immunity by themaninthedark on Thursday February 03, 2022 @11:40AM (#30194687)
Preface by saying the I don't agree with Trump on a lot of things.

Lets look at this from a parenting perspective. If i have a child who misbehaves often, is it appropriate for me to punish them when they do something good?

Holding the media to the same accountability, if Trump is saying stupid/outrageous/provocative things, then lambast him when he says those things. But if the media lambasts him when he is saying something reasonable, then that is on the media.

I think most of the annoyance I see in the thread is because there was blame being assigned to Trump or even someone on the same stage as him because they were on that stage with him.

>One of the worst things about Donald Trump was that if he or anyone adjacent to him actually said anything good, it immediately became toxic.

So rather than examining an idea based on the merits, ideas were discarded due to the messenger or the who the messenger associated with.

Re:What the Omicron wave is revealing about human immunity by hdjjhhvvhga on Thursday February 03, 2022 @01:22PM (#30196386)
Yes, I fully agree: criticizing Trump when when he was saying/doing something that makes sense just because it's Trump was very stupid.
Re:What the Omicron wave is revealing about human immunity by Supermancho on Thursday February 03, 2022 @11:53AM (#30194889)
Modified for context, the german adage holds. If you have Trump and 3 people talking at a table, you have 4 Trumpers talking at a table.
Re:What the Omicron wave is revealing about human immunity by kingsloi on Thursday February 03, 2022 @10:56AM (#30194008)
What about things said by them directly, their Twitter, etc?
Re:What the Omicron wave is revealing about human immunity by 62951413 on Thursday February 03, 2022 @02:19PM (#30197323)
70M people would like a word with you.

Don't confuse legacy media propaganda with what regular people think. Especially when you hear newspeak.

Re:What the Omicron wave is revealing about human immunity by krapp on Thursday February 03, 2022 @02:47PM (#30197760)
And 230M people would like a word with you.

Trumpists seem to forget that neither their movement nor their President have ever had the support of the American majority, much less of all "regular people." Never even the popular vote.

Re:What the Omicron wave is revealing about human immunity by TMWNN on Thursday February 03, 2022 @07:34PM (#30201172)
>Trumpists seem to forget that neither their movement nor their President have ever had the support of the American majority, much less of all "regular people." Never even the popular vote.

Neither did Hillary, who won 48% of the popular vote in 2016 to Trump's 46%. Does the fact that not until 2020 did Trump's opponent win a majority of the popular vote invalidate the validity of the opposition until then?

Re:What the Omicron wave is revealing about human immunity by ben_w on Thursday February 03, 2022 @10:32AM (#30193673)
While true, “some level of lasting immunity” is not necessarily all that useful. Norovirus infection and recovery for example, only last 6-24 months. I don’t know what the long term immune system response is for covid, but I do know that planning in general needs to be for the more pessimistic end of what is seems possible, and that quite a lot seemed possible in the early days of the pandemic.
Re:What the Omicron wave is revealing about human immunity by skocznymroczny on Thursday February 03, 2022 @11:06AM (#30194166)
Why the "only" wording? Seems like the covid vaccines don't even last this much, and they are praised.
Re:What the Omicron wave is revealing about human immunity by darkcha0s on Thursday February 03, 2022 @11:24AM (#30194412)
I'm guessing because they give you protection without actually catching the potentially harmful virus in the first place?
Re:What the Omicron wave is revealing about human immunity by chucksta on Thursday February 03, 2022 @11:44AM (#30194755)
No they used "only" as in "not very long". The question is asking how can you say it's not very long when the covid vaccination lasts less than a year in comparison
Re:What the Omicron wave is revealing about human immunity by ben_w on Friday February 04, 2022 @03:24AM (#30204206)
6 months is pretty short in both cases, but I think darkcha0s has me right, the cost is much lower in the vaccination case.

For a much most positive example of how that matters:

“How long did he retire for?“ “Only six months“

vs.

“How long did he go on holiday for?“ “Only six months“

Re:What the Omicron wave is revealing about human immunity by SigmundA on Thursday February 03, 2022 @11:24AM (#30194425)
Covid vaccines have less side effects than the virus so are still superior option, hence the praise.
Re:What the Omicron wave is revealing about human immunity by robrorcroptrer on Thursday February 03, 2022 @11:33AM (#30194555)
What if I had prior infection of Covid before vaccines were available? Why would I need to be forced to be vaccinated? Given that my health care system actually registers this prior infection. While we don't have vaccines for everyone in the world.
Re:What the Omicron wave is revealing about human immunity by SigmundA on Thursday February 03, 2022 @11:50AM (#30194842)
Getting Covid should be treated as though you got a vaccine based on the data I have seen, which also means its immunity effects wanes over time and would need to be boosted periodically either by reinfection or vaccine, again the vaccine being the safer approach.

Whether or not you should be "forced" to take it should be based on risk to others in the situation that it is being forced, just like you are "forced" to not speed while driving on a public highway.

I am not sure what the current latest scientific data is but my understanding is that virus and vaccine both reduce the risk of a subsequent infection, spreading the virus if infected and getting severe outcomes requires hospitalization (which reduces hospital capacity). Since this protective effect fades in both circumstances a recent booster would need to be "forced" if not recently having been infected assuming there is no issue with vaccine supply.

Re:What the Omicron wave is revealing about human immunity by naasking on Thursday February 03, 2022 @12:07PM (#30195110)
> Whether or not you should be "forced" to take it should be based on risk to others in the situation that it is being forced, just like you are "forced" to not speed while driving on a public highway.

I really wish people would stop using this analogy. Driving is a privilege not a right, and you earn that privilege by following the rules.

Living without compulsory medical procedures is a right, not a privilege, so it's the complete opposite case. You need a better analogy.

Re:What the Omicron wave is revealing about human immunity by SigmundA on Thursday February 03, 2022 @01:14PM (#30196253)
In the US the mandates allow a choice to either vaccinate or get regular testing. No one is being made to take a vaccine against their will in the US at least, they must however take precautions to protect others from their risky behavior.

You have a right to bear arms here in the US that does not mean you can shoot them in a public place because that endangers others. Typically rights have limits when they impose on others rights.

Working is a privilege was well not a right, you have no right to a job at an employer (at least in the US). So the analogy fits as a privilege but it also works as a right since neither are absolute and are typically limited when they effect others around you negatively.

Re:What the Omicron wave is revealing about human immunity by naasking on Thursday February 03, 2022 @01:24PM (#30196418)
I agree rights have limits when they conflict with other rights. However the right to work is a right under the UN human rights code. That doesn't mean you have a right to work at any particular place, but it does mean if vaccines are a prerequisite for any kind of work, either by government fiat or by broad corporate consensus, that would be a violation of human rights. Using tests to balance vaccines is one way to address that, but some countries don't even take those considerations and want to blanket mandate vaccines.
Re:What the Omicron wave is revealing about human immunity by SigmundA on Thursday February 03, 2022 @01:46PM (#30196767)
If it where a prerequisite to vaccinate with no other choice to find work anywhere (even remote from home jobs) or even say a majority of places I might agree, but that is not even close to the case here in the US.

I think the UN humans rights could also be interpreted as I having the right to a safe work environment and conversely if I where forced to work in a common office space with unvaccinated / untested people that would also violate my rights.

Re:What the Omicron wave is revealing about human immunity by naasking on Thursday February 03, 2022 @02:45PM (#30197738)
As I said, the US is not the only place that's discussing or implementing mandates, and other places are less flexible in how they're applying them.

Secondly, the very notion that you can have an expectation of not getting infected from someone else is intrinsically untenable. Just try to define what characteristics a pathogen must have before vaccines are mandatory. Why set the bar at COVID's fatality rate, why not the flu? Why not the common cold? Is fatality rate really the right metric? What about number of post infection complications?

Furthermore, what if we say the COVID rate is the cutoff, what if you have comorbidities that increase your chances of death, does that increase the obligation of your workmates to get vaccinated or is that your problem? I think you know which way the rhetoric is going, but these answers are far from obvious.

Re:What the Omicron wave is revealing about human immunity by SigmundA on Thursday February 03, 2022 @04:04PM (#30198819)
So which places are you talking about so I know what I can agree or disagree with?

This whole thing seems like continuum fallacy [1]. Just like everything we must all agree on a cutoff because the real world doesn't have neat black and white thresholds, covid is different from the flu that much is obvious and reaches my threshold for requiring vaccination / testing mandates at least in its current form. Do agree that a disease can be deadly enough to require it? If so what is your threshold before the mandate should be allowed?

I am willing to discuss what metrics would help come to consensus as a society, buts its not like requiring vaccines or other preventative measures for certain activities is some foreign concept.

[1] https://en.wikipedia.org/wiki/Sorites_paradox

Re:What the Omicron wave is revealing about human immunity by naasking on Friday February 04, 2022 @08:31AM (#30206537)
> This whole thing seems like continuum fallacy [1]. Just like everything we must all agree on a cutoff because the real world doesn't have neat black and white thresholds

No we don't. This assumes moral obligations are decided by an evaluation of their consequences, aka consequentialism. This is far from the only type of ethics, and permits problematic inferences (see the "Repugnant conclusion").

For instance, a Kantian would reject entirely the notion that such a cutoff is coherent. People who are trying to compel vaccines are merely using other people for their own ends (herd immunity to get back to normal), rather than treating them as ends in themselves. We should strongly encourage and persuade vaccination, but never compel them by coercive means under this ethics. Universalizing "no vaccination" does not result in a paradox, therefore it is not a moral duty under Kantianism.

There are equally compelling formulations of deontology and virtue ethics under which your sort of consequentialist argument also fails, so I'm just not convinced that it's some kind of inevitability.

Re:What the Omicron wave is revealing about human immunity by SigmundA on Friday February 04, 2022 @10:15AM (#30207752)
>We should strongly encourage and persuade vaccination, but never compel them by coercive means under this ethics.

So you don't believe a person should be compelled to be vaccinated or otherwise stay away from other people unless tested for infection no matter how contagious and deadly the disease? That is, forced quarantine should never be allowed under any circumstance regardless of disease?

Why should a person be free to infect others through their unabridged freedom yet one should not have the freedom to drive while drunk? People compelling others to travel sober is also using them as a means to their own ends (not being killed by drunk driver) even though they can take their own precautions (seat belts, air bags, safer cars, avoiding certain areas, they themselves not being drunk). No one is forcing anyone to be sober (in the US) just not to drive on public roads. You are not free to do whatever you want in a society with others there are limits put on your personal freedom so as not to endanger others, there is always a valid debate about what those limits should be, no different here, but there have to be agreed limits or nothing works.

Re:What the Omicron wave is revealing about human immunity by naasking on Friday February 04, 2022 @10:35AM (#30208088)
> So you don't believe a person should be compelled to be vaccinated or otherwise stay away from other people unless tested for infection no matter how contagious and deadly the disease?

What I believe is that the truth is far from obvious, and I'm describing how different ethics reach different conclusions for what is true. Thus, it's far from obvious that the choices you describe are the truth or "moral", so much as convenient and expedient. These are not the same thing.

> Why should a person be free to infect others through their unabridged freedom

Freedom is not unabridged, it simply has different limits under different ethics.

> yet one should not have the freedom to drive while drunk?

I already addressed this in my very first reply to you.

Re:What the Omicron wave is revealing about human immunity by spookthesunset on Thursday February 03, 2022 @05:25PM (#30199908)
> they must however take precautions to protect others from their risky behavior

If the vaccine was so good at protecting others, why the hell do vaccinated people still need to wear a mask? How is it even ethical to force people to vaccinate in order to function in society and yet still require them to wear a mask? Seems kind of bullshit to me.

Re:What the Omicron wave is revealing about human immunity by ben_w on Friday February 04, 2022 @03:12AM (#30204129)
First, because the vaccines are 80-95% effective in any specific individual (if boosted, potentially much less if not) and that isn’t good enough for society as a whole until the vaccine uptake is higher.

Second, I’ve never really understood why people are all that upset about mask mandates. It’s just clothing. Heck, in winter they are a vast improvement over scarves even without any disease concerns.

(Curiously, last-but-one time I wrote something similar here, someone took so much offence they tried to anonymously wish harm upon me via comments on my blog).

Re:What the Omicron wave is revealing about human immunity by aakresearch on Friday February 04, 2022 @04:36AM (#30204682)
> First, because the vaccines are 80-95% effective in any specific individual (if boosted, potentially much less if not) and that isn’t good enough for society as a whole until the vaccine uptake is higher.

That's a theoretical model. A hypothesis, most likely unattainable. Conveniently so, because it creates the whole lot of scapegoats.

> Second, I’ve never really understood why people are all that upset about mask mandates. It’s just clothing.

It is not. The net is full of accounts of people telling out precisely what is wrong with masks for them. On HN, on reddit, anywhere. If you wanted to understand, you have plenty of material to read. You, most likely, simply couldn't be bothered. That, or we're just different species.

> (Curiously, last-but-one time I wrote something similar here, someone took so much offence they tried to anonymously wish harm upon me via comments on my blog).

I'm sorry to hear that. They shouldn't have done it. However, this comment of yours is very dismissive to the concerns that some people perceive as fight-or-flight matter. Some choose to fight, event in such inappropriate and misdirected way.

Re:What the Omicron wave is revealing about human immunity by ben_w on Friday February 04, 2022 @07:19AM (#30205846)
> That's a theoretical model. A hypothesis, most likely unattainable.

“Theoretical model” is a tautology.

And it really should be attainable: We’ve successfully eradicated smallpox worldwide, we are close to doing that with polio, and many other illnesses have been eradicated from certain regions via vaccination programs. This is a thing we can do if we try.

> It is not. The net is full of accounts of people telling out precisely what is wrong with masks for them

What I see is always in one of the following categories:

• People asserting that other people (never themselves) with asthma or similar breathing issues can’t wear them, even though literally everyone I know who has asthma or who uses a CPAP machine is actually fine with masks, to the extent that in many cases they get angry with anti-maskers risking giving them covid. Occasionally I also see anti-maskers also asserting that masks make it difficult for children to learn facial expressions in school, which, while superficially plausible, still seems to fail to against reality.

• People who have decided everything about this is a political meme and not real, like this: https://www.gettyimages.co.uk/detail/news-photo/anti-mask-pr...

• People claiming that wearing masks lower blog oxygen levels despite all the evidence from e.g. surgeons, furries (two groups I would not have expected to list together before actually doing so).

It may be that all the above categories have totally overwhelmed real personal anecdotes of people who personally are unable to wear masks. I have no doubt, for example, that there is at least one person with no external nose or ear cartilage for a mask to hold against and who for whatever reason has not had plastic surgery. But this is not what I have ever seen. Always one of the above, on every occasion.

Re:What the Omicron wave is revealing about human immunity by naasking on Friday February 04, 2022 @08:11AM (#30206351)
> We’ve successfully eradicated smallpox worldwide, we are close to doing that with polio, and many other illnesses have been eradicated from certain regions via vaccination programs. This is a thing we can do if we try.

Eradicating COVID is not possible because it's in animal reservoirs.

> People asserting that other people (never themselves) with asthma or similar breathing issues can’t wear them

I have had occasions when it became extremely uncomfortable and even triggered an allergic reaction. Universal, effective mask use is not as simple as it's been portrayed.

Furthermore, the evidence that such universal mandates actually work is not as compelling as you think.

> Occasionally I also see anti-maskers also asserting that masks make it difficult for children to learn facial expressions in school, which, while superficially plausible, still seems to fail to against reality.

I don't know what evidence you think proves this claim.

> everyone I know who has asthma or who uses a CPAP machine is actually fine with masks, to the extent that in many cases they get angry with anti-maskers risking giving them covid

Of course they get angry, they're at higher risk and they're scared. They are risking COVID just by going outside. I'm not sure how that translates into an obligation on others to lower their risk. Of course they want others to take those steps, but that doesn't mean those demands are justifiable. If they want to lower their risk, they can take steps to protect themselves, by getting vaccinated, limiting their contact, etc.

> People claiming that wearing masks lower blog oxygen levels despite all the evidence from e.g. surgeons, furries

A properly fitted mask that actually works against COVID absolutely does lower blood oxygen. The whole point is to restrict air flow to prevent aerosolized droplets from passing through. I've measured it myself using a blood oxygen meter while wearing an N95 mask.

Of course poorly fitted masks don't lower blood oxygen, but those also aren't that effective at reducing spread. The comparison to surgeons is disingenuous, they've had years of exposure and training to learn how to operate under such conditions.

Re:What the Omicron wave is revealing about human immunity by aakresearch on Friday February 04, 2022 @09:06AM (#30206883)
> “Theoretical model” is a tautology.

Of course.

> And it really should be attainable: We’ve successfully eradicated smallpox worldwide, we are close to doing that with polio, and many other illnesses have been eradicated from certain regions via vaccination programs. This is a thing we can do if we try.

It is a wonderful thing, a blessing, that we were so lucky with eradication of some terrible diseases. Eradication is really a side effect of a vaccination program hitting a sweet spot within vaccine-pathogen space:

- sufficiently strong vaccine, close to sterilizing

- slowly mutating pathogen

- sufficiently scary illness, to the point that high vax uptake is attainable without coercion

- some evolutionary luck

Of the above properties the current virus-vax duo possesses approximately none, so we could try all we wanted and still remain unsuccessful. Trying hard is a necessary, but by no means sufficient condition.

> What I see is always in one of the following categories

That's impressively selective vision on your part.

> People who have decided everything about this is a political meme and not real

They may be real to an extent AND a political meme at the same time. People make different judgements all the time.

> People claiming that wearing masks lower blog oxygen levels

This looks plausible, however I may agree that some people are merely claiming it. But what it all really is - and you'd figure it out if you were willing to see beyond preconceptions - for many it just a clumsy attempt to speak the "rational" language. Because mask-enthusiasts for some reason are not willing to entertain idea that mask wearing is a huge mental burden. I'll spare you of my personal experience, mainly because I don't want it to be dismissed again. I assure you, there are people who share and understand it, and mask-enthusiasts do not have a monopoly on value judgement.

My question is - what needs to happen for our problems to be recognized? People already are killing themselves, some are still hanging by a thread, but may not be for long. I suspect that the answer would be - it does not matter, our problems do not matter. This is fine, I'm learning to leave with it, learning to see the other side as completely different species, with all that follows. And what follows does not look good.

Re:What the Omicron wave is revealing about human immunity by was8309 on Thursday February 03, 2022 @12:25PM (#30195440)
aren't vaccine mandates for participation in a shared environment - like work?
Re:What the Omicron wave is revealing about human immunity by naasking on Thursday February 03, 2022 @12:35PM (#30195616)
Mandates are being used in many different ways depending on the country. But even if it were limited to work, the right to work is also recognized as a human right so the analogy to driving still fails.
Re:What the Omicron wave is revealing about human immunity by boomboomsubban on Thursday February 03, 2022 @11:49AM (#30194827)
Given that the poster said norovirus immunity lasts from 6-24 months, having been infected before the vaccine wouldn't guarantee you're safe.

And while sure they could push back your vaccine requirement a few months, that'd require a fair amount of additional overhead and add an additional risk of having gotten a false diagnosis.

Re:What the Omicron wave is revealing about human immunity by KptMarchewa on Thursday February 03, 2022 @11:48AM (#30194807)
We have way more than enough for anyone who wants it.
Re:What the Omicron wave is revealing about human immunity by ViViDboarder on Friday February 04, 2022 @05:17PM (#30214138)
But did it? I don’t ever remember T-cells being considered anything close to conspiracy theories, nor their importance being downplayed.