Re:Moderna’s HIV vaccine has officially begun human trials
by chucksmash on Monday January 31, 2022 @03:33PM
(#30153881)
Presumably the viral load required for transmission is greater than the viral load required for detection.
[ Parent
| on HN ]
Re:Moderna’s HIV vaccine has officially begun human trials
by whimsicalism on Monday January 31, 2022 @04:06PM
(#30154342)
My guess is it is more of a probabilistic thing than a strict threshold.
Re:Moderna’s HIV vaccine has officially begun human trials
by staticassertion on Monday January 31, 2022 @06:25PM
(#30156289)
Yes. Super equals was inappropriate imo.
Re:Moderna’s HIV vaccine has officially begun human trials
by whimsicalism on Monday January 31, 2022 @08:59PM
(#30157685)
I don't know that it's inappropriate.
I mean, technically, there's always a possibility of getting HIV. Particles in your body could spontaneously quantum tunnel at the same time into the form of an HIV virus. This is basically impossible, but not actually (p = 0.00) impossible.
At some point you have to look at a probability and say - that's basically not transmissible.
Re:Moderna’s HIV vaccine has officially begun human trials
by dillondoyle on Monday January 31, 2022 @10:32PM
(#30158310)
I mean just based on the definition that seems like the literal meaning to me. But i'm not a PHD
Re:Moderna’s HIV vaccine has officially begun human trials
by stjohnswarts on Monday January 31, 2022 @04:13PM
(#30154448)
That seems like a big if? maybe 0.5% of people actually are succeptable to the lowered viral load. Have studies been done that would detect such a population?
Re:Moderna’s HIV vaccine has officially begun human trials
by mlyle on Monday January 31, 2022 @04:34PM
(#30154785)
One reason we believe this is that we can typically detect virus quantities way too small to reliably replicate in culture, and believe that in vivo infection is even harder than in culture (because of innate immune response and the body not being composed just of the most susceptible cells).
You generally can't measure infectious dose directly without a highly unethical challenge study. You can sometimes know concentrations that did or didn't result in infection in various real world scenarios, and sometimes you have circumstantial evidence (e.g. you can know how much virus a person sheds, and what proportion of a room with certain ventilation quantities got infected).
Re:Moderna’s HIV vaccine has officially begun human trials
by makomk on Monday January 31, 2022 @07:01PM
(#30156692)
The usual way of achieving undetectable viral load is via anti-retroviral drugs and I think this works in most people, at least so long as they get early enough treatment and keep getting it. The main reason to measure viral load in the first place is to get an idea of how well the drugs are working and if they need to be changed.
Re:Moderna’s HIV vaccine has officially begun human trials
by scaredginger on Monday January 31, 2022 @06:06PM
(#30156083)
People on ART also often (perhaps usually) have undetectable viral loads
Re:Moderna’s HIV vaccine has officially begun human trials
by jxramos on Monday January 31, 2022 @04:30PM
(#30154711)
that's what I would think, it's got to be quantifiable: some sensitivity metric of the concentration of virus particles the device can detect vs the minimum quantity which is needed for infection. It's clear we can articulate these matters in the abstract, how does one go about actually measuring such a thing?