I never really gave much thought to how dangerous this stuff was until a year or so ago, Eric Engstrom (one of the creators of DirectX and a personal hero of mine) accidentally overdosed and died from it:

> He died at a hospital in Seattle. His wife, Cindy Engstrom, said he had injured one of his feet in October, accidentally took too much Tylenol for pain relief and suffered liver damage.

https://news.ycombinator.com/item?id=25423712