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Re:Moderna’s HIV vaccine has officially begun human trials by arcticbull on Monday January 31, 2022 @01:59PM (#30152467)
The one that really surprises me that people take like candy is Tylenol/Panadol/Paracetamol/Acetaminophen. It's the leading cause of acute liver failure in the US. Among common OTCs, its active dose is I believe the closest to its lethal dose. Just 2-3X the recommended daily upper limit can cause liver damage, and when taken around alcohol, the toxicity is dramatically higher.

I strongly doubt that Acetaminophen would be approved as an OTC drug if proposed today.

Re:Moderna’s HIV vaccine has officially begun human trials by Firmwarrior on Monday January 31, 2022 @02:06PM (#30152588)
I never really gave much thought to how dangerous this stuff was until a year or so ago, Eric Engstrom (one of the creators of DirectX and a personal hero of mine) accidentally overdosed and died from it:

> He died at a hospital in Seattle. His wife, Cindy Engstrom, said he had injured one of his feet in October, accidentally took too much Tylenol for pain relief and suffered liver damage.

https://news.ycombinator.com/item?id=25423712

Re:Moderna’s HIV vaccine has officially begun human trials by tialaramex on Monday January 31, 2022 @06:22PM (#30156261)
On the other hand, for some people Paracetamol (in the US Acetaminophen) works very well, and it's really cheap. So although there's been increasing oversight to reduce overdose deaths, I think you're going to keep seeing it available OTC in some form even though you're right it'd never get OK'd if invented today.

Once I realise that the Flu (or whatever) is inducing enough pain that I can't ignore it, or I start to run a serious fever, I take paracetamol to get on top of that, usually in the form of Lemsip because I'm bad at taking pills, Lemsip is cheap, and none of the other ingredients in ordinary Lemsip these days really do anything much, just the paracetamol.

I find maybe 1 or at most 2 of the "maximum" 1g (= 1000mg) doses a day gets the job done, which is well inside the indicated limits.

None of the OTC alternatives do it for me, they're not useless but the effect from the indicated dose is far reduced so I'm glad to have paracetamol. I've had fentanyl after surgery, which was certainly effective but seems like a very bad idea to have around the house, and Entonox after a road accident which again, effective but seems like a bad idea for OTC usage.

Re:Moderna’s HIV vaccine has officially begun human trials by epgui on Monday January 31, 2022 @08:18PM (#30157390)
I think they're safe enough, personally... But most people need some risk calibration.

Popping NSAIDs multiple times a week on a regular basis is definitely not good, and yet the same people who do that are often afraid of vaccines.

People are seriously clueless about relative risks.