1. The vaccines will become decreasingly relevant, unless we can provide technology to update vaccines as quickly as they mutate. Even then, it'll be like flu vaccines. They'll help, but won't stop the spread.

2. Barring some technological breakthrough, Covid will never go away. We'll all contract it. Then it will mutate and well contact it again in the next year, and the next, forever

As such, our current policies are ineffective, and lockdown is by no means sustainable forever.

At this point we've got well established indications of omicron being an unserious infection (sparing the lungs entirely, being no more than a bad cold for the vast majority of those who contract it). Not 1000% confirmed, of course ongoing study is warranted, but it would be shocking if omicron turns out to be a serious driver of illness and death.

But policy makers and media commentators are allergic to optimism on what this implies long term, so we are stuck in a state of alarm.

Interesting, I haven't been following the pandemic as closely as I used to, but I was under the impression that the existing mRNA vaccines still work fairly well against new variants (including omicron), but that effectiveness goes down after 6 months (hence boosters). I'm not really sure if "effectiveness" is in preventing severe illness or transmission.

https://pubs.acs.org/doi/10.1021/acs.jcim.1c01451#

I should have said "relatively effective", since I'm also under the impression that the vaccines weren't super effective at reducing transmission of the original variant (compared to vaccines against other infections). But I also haven't seen much data, I vaguely remember hearing something from the WHO like "60% effective at reducing transmission of original variant, 40% effective against Delta", but I don't remember.

Prior to this pandemic the layman understanding of a vaccine was that they generally prevented you from “contracting” the disease. You get the shot, you don’t get the disease. We were basically sold this notion for the mRNA vaccines early in 2021. However, the reality was different. Whether by way of mutation, or simply by the way the mRNA vaccines only work against a specific portion of the virus, mRNA tech seems to not be as effective at the prevention of infection but better at the prevention of severe infection. In essence, it’s not a “vaccine” as the public understood the word. However, it is a tool, and still a relevant one in diminishing the severity of the pandemic, it’s just a shame that the expectations that were set were way off.

I also don’t know of a time in history where a vaccine was developed for an emerging disease as opposed to one that was already endemic with a lot of natural immunity around.

I agree that the public was misled as to how effective vaccines would be at preventing transmission. Especially when the CDC said that fully vaccinated people didn't need to wear masks.

But how much more effective are traditional vaccines at preventing spread of illnesses? Wikipedia pointed me to this CDC page:

> The MMR vaccine is very safe and effective. Two doses of MMR vaccine are about 97% effective at preventing measles; one dose is about 93% effective. [0]

[0]: https://www.cdc.gov/vaccines/vpd/measles/index.html

I was always under the impression that traditional vaccines were really effective, enough that the virus stops spreading eventually, but not enough that you are almost totally incapable of spreading the virus or even getting sick. Like the outbreaks in disneyland, obviously they only happened because of people being unvaccinated, but my understanding is that vaccinated people can still get sick from it. I found this Washington Post article:

> A 2015 measles outbreak linked to Disneyland led to 147 cases in multiple states as well as in Mexico and Canada. Many of those who were sickened were unvaccinated or did not know their vaccine record, according to the Centers for Disease Control and Prevention.

[1]: https://www.washingtonpost.com/health/2019/08/24/tourist-inf...

At this stage, despite being fully vaccinated and boosted, I absolutely expect to be exposed to and symptomatic from Omicron in the next 45 days.

If we compare these vaccines to non-existent ones that we believe should be better, then we are disappointed. If we compare them to the possibility of having developed worse vaccines, then we would be elated.

That makes people skeptical.

Right now I know probably 5-6x the number of vaccinated people who have had Covid post vaccination than people who had it prior to the vaccine being available. I know unvaccinated people who have never had Covid, and vaccinated people who have had it twice…post vaccination.

Am I vaccinated, yes. Am I skeptical of the existing vaccines to prevent me from getting Covid and ending the pandemic, yes.

Maybe we have different sources of information. I've never heard anyone claim that the vaccine will end the disease or prevent them from catching it. I've heard that the vaccines will decrease the likelihood of becoming sick which it does.

> Then the reality is discovered to be that it doesn’t do any of those things, but it does provide a milder experience…and oh by the way, and that efficacy only lasts a few months, so go get another booster dose ASAP.

I assume by "provide a milder experience" you mean "decrease the likelihood of becoming seriously ill". That's been the sales pitch that I heard for vaccines since the beginning. Similarly, it was never known how long the vaccines would remain effective.

> Right now I know probably 5-6x the number of vaccinated people who have had Covid post vaccination than people who had it prior to the vaccine being available. I know unvaccinated people who have never had Covid, and vaccinated people who have had it twice…post vaccination.

So what? Had those people not been vaccinated, then they probably would have been _more_ likely to develop serious disease.

I honestly just don't understand your point. The vaccines are not doing as well as many had hoped. Personally I had hoped that the entire pandemic would have gone away once vaccines became available, but that hope was clearly misplaced. But that just means that I was mistaken and that I need to change my perception of what this pandemic will mean going forward. I think you should do so as well.

Where did you get that hope from? You said the information you were getting did not provide that hope, that it set expectations to what they are. If you didn’t get that idea from the authorities touting the vaccine…where did you get it? Likely it was the assumption that these vaccines would work like all the others.

That is my point.

It was optimism. I was hoping that the strains wouldn't evolve so quickly. My optimism was misplaced.

> Likely it was the assumption that these vaccines would work like all the others.

Ignoring the methods (e.g. mrna), this vaccine _does_ work like all the others. It increases the likelihood that your body will be able to successfully fight off an infection without it progressing to serious/dangerous illness. What vaccine doesn't work this way? All viruses/bacteria roughly do the following:

1. They infect some percentage of people. 2. After some period of time they eventually make those people contagious (so spread is possible). 2. They mutate at a certain rate.

If viruses mutate very quickly, vaccines have trouble dealing with them. If they are highly contagious they have a lot of opportunity to spread and mutate. If they are able to quickly make hosts highly contagious then they have even more opportunity to spread an mutate.

You seem to imagine a "vaccine" to be something that is able to entirely protect a host from the disease and entirely protect a host from spreading it. This just isn't the case. The fact that there are vaccines for diseases which mutate/spread/etc. slowly enough so that you can _incorrectly_ believe this is a success of modern science. But the fact is that it never was and never will be true. Covid is a bitch and it will clearly take some time (if ever) to get it under control.

No, I simply trusted in the advertised protection against Covid infection by the mRNA vaccines would exceed 90%, I was hopeful that if I was one of the unlucky 10% to contract it, that the case would be mild. I was trusting what we were being told. When the reality set in, so did skepticism. Optimism to realism.

https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...

“Based on evidence from clinical trials, in people ages 18 years and older, the Moderna COVID-19 vaccine was 94.1% effective at preventing laboratory-confirmed COVID-19 infection in people who received two doses and had no evidence of being previously infected.”

I guess I don’t understand someone who claims they knew that the vaccines would not be effective in stopping the spread of the virus, but were still optimistic and hopeful that the vaccines would end the pandemic. You generally don’t go from realism to optimism. It’s usually the other way around.

afaik the flu vaccine has for decades been advertised as:

"might not always prevent, but will usually lessen symptoms"

So I'm not sure why people think this is a new thing.

Vaccines like MMR and others are understood to be generally preventative and rarely need booster if after initial doses.

Think about things that generally require boosters…they are almost always referred to by the laymen as “shots”. Nobody calls the tetnus shot a tetnus “vaccine”.

And coronavirus is also understood to be seasonal.

However, in spite of all that, I agree that the official messaging throughout this pandemic has been so inconsistent - from masking to "two weeks to flatten the curve" to "boosters" - that the public does have a right to be skeptical and exhausted.

As people become infected and gain immunity (in reality not always perfectly and not necessarily until the end of times, but on average they'll definitively do, and right now we're only talking about a simplified thought model anyway), they drop out of the pool of people available for further infections and therefore slow down the growth rate.

While still only a simplified approximation, logistic growth is therefore a better model than naive unchecked exponential growth, and the maximum case rate will be somewhat lower than "half the population gets infected in the last doubling step".

Specifically I'm wondering what the maximum number of cases in a short period is likely. I ask because I was shocked to hear that the number of ICU beds in a major city of 1M people in Canada was only a few hundred (or maybe that was total hospital beds? I can't remember). So it seems like you need to keep your "hospitalizations per population" number down to less than the ratio of "hospital beds per population".

Certainly I was wrong in saying "everyone will get it" in a few months because of the logistic growth curve, but it looks like a significant portion of the population could still be infected within the same period, even if you remove the 6% (Canada) to 20% (USA) people who have already been infected? And even if everyone is fully vaccinated, can the number of them that end up in hospital come close to the total capacity? It seems like we're already getting close to capacity.

As for your original question – I've been wondering about the same thing.

My personal back-of-the-envelope calculation was more along the lines of "If the vaccine is 90 % effective (the numbers given for Germany during the Delta wave and before the start of the third round of vaccinations were closer to 90 than to 95 %) in preventing hospitalisation and 75 % (for example) of the population are vaccinated, it means that case numbers in hospitals are 75 % x 1 + 25 % x 10 = 3.25 times higher than they would be with full vaccinations.", though I suppose there are enough holes that could be poked into that calculation, too.

A three-fold reduction in case numbers is nothing to be sneezed at, but on the other hand as long as the spread is still behaving mostly exponentially instead of turning into logistic growth and slowing down again that's only one-and-a-half doubling periods, so not that much of a buffer, either. Of course the vaccines are also somewhat (if not as well as was originally hoped) preventing some spread, so with full vaccination growth rates themselves would also be lower and hospital cases be reduced by more than threefold, but whether that's then enough, who knows?

In the end I decided there's no point in worrying myself further here, because there are too many unknown factors in getting a reasonable result that I can't easily answer and ultimately I have no desire in becoming a full-time epidemiologist.

- it might be that two shots 6 months apart are more effective. i.e. skipping the 2nd shot in the 3 shot series would be fine.

- it might be that a nasal vaccine would be more effective than an injected one. We just don't have one of those yet.