I guess it depends on what you're configuring. I'm using microk8s at work and the part of my team that has to deal with the VM-encapsulated version that runs on Mac or Windows is always mired in configuration woes. Same goes for docker.

Granted, that's a far cry from touchpad configs--but if you keep your dotfiles in git then touchpad config is something you only have to once (per touchpad that you own).