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Re:New Concerning Variant: B.1.1.529 by fragmede on Friday November 26, 2021 @05:36PM (#29354965)
Here's a link to a real actual science study that used tuberculosis-sized particles and found filtration efficiencies of 99.5% or higher by N95 masks. Which isn't minor. It's been over a year. If you're not using an N95, you're doing yourself and those around you a disservice.

https://pubmed.ncbi.nlm.nih.gov/9487666/

Re:New Concerning Variant: B.1.1.529 by timr on Friday November 26, 2021 @05:49PM (#29355068)
That's nice, but filtration efficiency =/= real-world efficiency. Unless you plan on super-glueing mask fabric to everyone's face holes, of course.

Also, last time I checked, most people aren't wearing N95 masks. Probably because they're annoying and difficult to wear.

> Which isn't minor. It's been over a year. If you're not using an N95, you're doing yourself and those around you a disservice.

I am vaccinated. Which brings up an important point: there is absolutely no evidence that a mask of any sort provides any benefit to those around me, a vaccinated person.

At some point, you have to put up evidence for your increasingly implausible claims -- you can't just keep leaning on lab studies of filtration efficiency. It's been two years now. Where is the real-world data backing your claims?

Re:New Concerning Variant: B.1.1.529 by Terretta on Friday November 26, 2021 @08:15PM (#29356156)
Feels like you’re slinging a lot of assertions without substantive evidence, seemingly asking people to “Google that for you”.

Among other things, vaccinated persons can and do contract, carry, and spread, during which a decent* mask does do its thing.

And who doesn’t wear an N95 class mask? I see about 2/3rds N95, KN95, or KF94s, 1/3 useless masks, appearing to be mostly correlated along economic lines ($2/masks vs. $0.50/masks).

PS. This is bigger than “fractions of a percent”:

https://jdrampage.org/real-world-covid-mask-trial-proves-mas...

* This shows lame mask are lame:

https://pubmed.ncbi.nlm.nih.gov/32512240/

Put those two concepts together, you get humdinger models suggesting:

“… if only around half of the population opted to wear respirator-type masks from the beginning of the pandemic, COVID-19 would have failed to establish in the United States.”

https://royalsocietypublishing.org/doi/10.1098/rsos.210699

(Would have needed closer to 2/3 with those sneeze guard ’surgical’ masks.)

Re:New Concerning Variant: B.1.1.529 by Wowfunhappy on Friday November 26, 2021 @09:11PM (#29356587)
> And who doesn’t wear an N95 class mask? I see about 2/3rds N95, KN95, or KF94s, 1/3 useless masks, appearing to be mostly correlated along economic lines ($2/masks vs. $0.50/masks).

I can't comment on the rest of the science, but fwiw, I live in NYC and I'd estimate that maybe 1 / 20 people I see on the street are wearing N95/KN95/KF94 masks. Everyone else just wears cloth masks, or paper surgical masks.

Re:New Concerning Variant: B.1.1.529 by Terretta on Friday November 26, 2021 @11:01PM (#29357282)
Sorry, yes, you’re right, it follows that there would be areas with 1/20 as you describe.
Re:New Concerning Variant: B.1.1.529 by Wowfunhappy on Saturday November 27, 2021 @05:53AM (#29359208)
I mean, I’m talking everywhere I go, throughout Manhattan and northern Brooklyn (haven’t been to the other burrows in a long time). Lots of very affluent areas.
Re:New Concerning Variant: B.1.1.529 by nradov on Friday November 26, 2021 @10:13PM (#29357007)
None of that is relevant. The virus is now endemic so everyone will eventually be exposed regardless of whether they wear masks in some situations.

https://www.medpagetoday.com/opinion/vinay-prasad/94646

Re:New Concerning Variant: B.1.1.529 by Terretta on Friday November 26, 2021 @10:55PM (#29357250)
It’s relevant to the point that was begin discussed.

TBC, I’d agree that your point, that of the article you shared, is valid. But it doesn’t pertain to the claims of inefficacy of masks outside a lab.

Re:New Concerning Variant: B.1.1.529 by timr on Saturday November 27, 2021 @01:43AM (#29358106)
> PS. This is bigger than “fractions of a percent”:

No, it isn't. If you'd bothered to read the content of the link I posted in the comment to which you're replying, you'd see that it's about the same paper.

That paper is mentioned numerous times in the thread you're commenting on, I've linked to it, as have others, and I've cited the absolute effect size: 0.09%.

The paper showed that there was an 11% drop on a baseline infection rate of 0.79%, in a fully unvaccinated population with very little natural immunity. It is the absolute best possible argument for masks, and it showed that cloth masks had no detectible effect, and that surgical masks had an effect size measured in tiny fractions of a percent.

Re:New Concerning Variant: B.1.1.529 by blagie on Friday November 26, 2021 @06:04PM (#29355210)
1) There are a lot of comfortable masks which have high filtration. They're used widely in Asia. It's no >99%, but it is >90% when used reasonably. If both sides use them, that brings viral loads down by >99%, though.

2) You're right that Americans are idiots who mostly can't tell the difference between a piece of cloth, which reduces viral loads marginally, and a proper mask.

3) Vaccinations have minimal impact on spread for extended in-door socialization (~30% reduction in odds of spread at this point). They do pretty well for reducing risk to you (e.g. death or hospitalization), and they seem to do pretty well for avoiding casual spread (e.g. passing someone on the street).

Re:New Concerning Variant: B.1.1.529 by stjohnswarts on Friday November 26, 2021 @10:12PM (#29356999)
You seem to be getting downvoted for no reason. Lot of angry people out there.
Re:New Concerning Variant: B.1.1.529 by nradov on Friday November 26, 2021 @05:46PM (#29355041)
And so what are you suggesting? Everyone wear N95 masks all the time forever?
Re:New Concerning Variant: B.1.1.529 by NikolaNovak on Friday November 26, 2021 @05:58PM (#29355151)
It's tricky.

- fwiw, I personally plan to wear n95 mask outside of home in enclosed public spaces for the foreseeable future, and for things like shopping etc (where I'm exposed to strangers) basically indefinitely / as long as social norms and laws will allow.

- I would like for strangers around me to wear masks. There's too much uncertainty and I don't know how to quantify and otherwise address risk from stranger e.g. In waiting / cashier line, or worse yet elevator (enforced enclosed proximity). I really see no good reason to be in an elevator with unmasked stranger.

- how long and where do we legally mandate masks? Whooeee, I'm glad I don't have to make that awful formal call! :-)

But yeah. If risk is forever, than at least some of us will use ways to mitigate the risk forever in turn. It's not binary, it's a sliding scale that's very individual. so... Yeah. Welcome to the new world! Cyberpunk dystopia future is here! :-)

Re:New Concerning Variant: B.1.1.529 by timr on Friday November 26, 2021 @06:02PM (#29355185)
> There's too much uncertainty and I don't know how to quantify and otherwise address risk from stranger

You know what would help with this? A randomized controlled trial. This isn't tricky at all, except that we can't do the science because it has become political, because people insist that they know the answer already! And if the study shows what they don't want to see, then they censor it, bury it, downvote it into oblivion, or...write missives about how they're going to ignore it.

Also, are you vaccinated? Yes? Then the answer is almost certainly no risk at all. This much we know from ~all of the data regarding vaccines and serious illness, worldwide.

Re:New Concerning Variant: B.1.1.529 by NikolaNovak on Friday November 26, 2021 @07:23PM (#29355809)
>>"Also, are you vaccinated? Yes? Then the answer is almost certainly no risk at all"

That is not my lay person interpretation of the currently best available data.

A vaccinated person can get infected, can get seriously ill, and can spread out to others more vulnerable. It helps, drastically, and I sure as heck got mine, but my understanding is that it does not confer individual invulnerability.

Re:New Concerning Variant: B.1.1.529 by timr on Saturday November 27, 2021 @01:49AM (#29358128)
> A vaccinated person can get infected, can get seriously ill, and can spread out to others more vulnerable.

I can get hit by a car when I walk down the street, but I've been doing it my entire life and I'm still here. I can die in a horrible plane crash when I fly, but I still do it. I can have a heart attack when I go to the gym, but it's still a net positive for my life.

Do you have a grasp on the actual risks involved here? You do realize that, even unvaccinated, unless you're elderly or obese or severely immunocompromised, the risk from this virus is measured in fractions of a percent, right? And if you've had even a single dose of an approved vaccine, you can take that number and divide it by 10?

At some point, you have to let the terror go.

> my understanding is that it does not confer individual invulnerability.

Who promised you invulnerability?

Re:New Concerning Variant: B.1.1.529 by NikolaNovak on Saturday November 27, 2021 @03:09PM (#29362933)
I think we agree on a base point of personal risk assessment. With that in mind, some people jaywalk, some take extra minute to get to a crossing. Some run across, some double check both sides. Some wear black pants and leather jacket at night, some have reflective strips. And it's all good. We share the old adage that "whoever drives faster than me is a maniac whoever drives slower is an idiot" - but most of us understand when pressed that different people have different risk acceptance in their life and that's ok.

The Thing that makes covid tricky is which actions am I making for myself vs others. Safety belt and helmet are largely for myself (but still enforced in many places due to agreed societal cost that goes beyond Individual). Mask, we don't have common universal agreement to yet. (this is not to say I don't have am opinion on it, but I understand looking around that while mainstream it's not universal).

So while I think we have agreement in framework, we may disagree on personal implementation. Mostly, I don't know that I agree with "at some point you have to let terror go". This ain't over yet, may never be over, so some mitigation steps may never be over, is the sobering world to raise offspring Into. Alberta took foot off the brake for just a little while and next thing they were begging other provinces for ICU spots. And there's a whole conplicated interlocked system of individual causes and effects rather than some simple binary rule that have rise to that reality.

Re:New Concerning Variant: B.1.1.529 by mrexroad on Saturday November 27, 2021 @12:58PM (#29362005)
When you cross a busy street, do you use crosswalks and obey the cross/don’t cross signal?
Re:New Concerning Variant: B.1.1.529 by timr on Saturday November 27, 2021 @03:11PM (#29362950)
Actually, no. I live in a big city. We're apparently all just free-wheeling, death-defying risk-takers here. YOLO.

But you make an excellent point: the average NYC citizen probably takes bigger risks crossing the street on a daily basis than she would by going un-masked.

Re:New Concerning Variant: B.1.1.529 by NikolaNovak on Friday November 26, 2021 @10:23PM (#29357063)
replying to "Gladinovax":

>>"I'm doing great without one. No need to worry about longterm risks from a rushed vaccine. 1 year does not equal 10. Ever."

There are categories of knowledge where I'm profoundly uninterested in any individual's experience (best friend or stranger on the internet alike:). Simply put - a person surviving Russian Roulette does not make playing Russian Roulette a good idea, no matter how convinced they are and loudly proclaimed that it worked out great for them :).

I do not know your situation - maybe you've gone hermit; maybe you're in an area of low risk; maybe you're being careful; maybe you're the one asshole around and everybody else is vaccinated/wearing mask/implementing lockdown while you're taking credit for not getting your sorry ass sick; or (most likely but I have no way of judging), you're just lucky - see the Russian roulette above.

But in risk evaluation of this sort, again, I'm far far more interested in verifiable statistics than individual's lived experience.Don't get me wrong - we can have a nice round of drinks and talk about how last year's been to us and approaches we've taken and it'll be interesting and we can share; but it's not a policy-guiding thing.

Re:New Concerning Variant: B.1.1.529 by PaulDavisThe1st on Saturday November 27, 2021 @01:19AM (#29357970)
> Also, are you vaccinated? Yes? Then the answer is almost certainly no risk at all.

As of the week before last, 28% of all hospitalizations in my state (NM) related to COVID19 involved fully vaccinated people.

Re:New Concerning Variant: B.1.1.529 by headmelted on Sunday November 28, 2021 @05:55PM (#29374059)
Isn’t this statistic in itself a little misleading though? Given that so many people are vaccinated now, the proportion of hospitalizations would be expected to trend higher in that group as the pool of unvaccinated people is shrinking at the same time.

Also, the eldest people (largely those most at risk of hospitalisation) are substantially more likely to have been vaccinated already, no?

Re:New Concerning Variant: B.1.1.529 by PaulDavisThe1st on Sunday November 28, 2021 @07:45PM (#29374995)
In the context of the claim that, once vaccinated, you are in "no risk at all" for symptomatic COVID19, I don't think it's misleading: significant numbers of fully vaccinated individuals can and do become sick with the disease. Ergo, even when fully vaccinated, you still face some risk.

None of this is an argument against vaccination, of course.

Re:New Concerning Variant: B.1.1.529 by vishho on Friday November 26, 2021 @06:28PM (#29355383)
We cannot do the science, because such a randomized test would be deeply unethical. Compare to having pregnant women smoke cigarettes to study effect on the fetus. You do this only afterwards with observational data.

Next to politization there is also public health, which is more of a management science than an emperical science. And economic concerns.

From all the data worldwide, you only reduce risk of hospitalization and death, not for spreading to your grandmother or catching it from a bypasser sneezing in your face. To act like there is no risk for the leaky vaccinated, is to actually increase your risk. Data shows that asymptomatic breakthrough infections are able to cause long-COVID. Now you did not even feel sick and gave your body and immune system rest to clear the virus. Very risky!

Re:New Concerning Variant: B.1.1.529 by timr on Friday November 26, 2021 @06:31PM (#29355402)
> We cannot do the science, because such a randomized test would be deeply unethical.

Thank you for perfectly illustrating the problem. I was actually sort of worried that people wouldn't take me seriously when I said that science has become so political that we actually can't do any. It sounds conspiratorial, doesn't it? But, alas:

1) I post results of RCTs showing that masks do little, if anything.

2) Someone replies that the evidence is insufficient for reasons X, Y, Z.

3) I say "great, let's gather more evidence to resolve those uncertainties".

4) Someone replies "we can't, it's unethical".

Quite a fine castle you've built on that cloud, good sir. Very safe indeed.

Re:New Concerning Variant: B.1.1.529 by Terretta on Friday November 26, 2021 @08:17PM (#29356173)
And yet, it’s been done:

In a First, Randomized Study Shows That Masks Reduce COVID-19 Infections

A large study co-authored by Yale SOM’s Jason Abaluck and Mushfiq Mobarak tested the effectiveness of a mask-promotion program in Bangladesh in increasing mask use and preventing symptomatic infections. The study found that masks significantly lower symptomatic infections, especially among older people and when surgical masks [instead of cloth] are used.

https://insights.som.yale.edu/insights/in-first-randomized-s...

Re:New Concerning Variant: B.1.1.529 by timr on Saturday November 27, 2021 @01:56AM (#29358165)
That's literally the study this thread is talking about. It's great that they did it -- it should have been done in early 2020, all over the world. We should have dozens of other studies just like it.

The fact that we don't is an indication of how hard it's been to pursue any sort of science in this area. Almost nobody funds it, you can't get it published if it doesn't fit the public health narrative, and even if you do, the the news media won't report on it, and it might just get censored on social media.

Re:New Concerning Variant: B.1.1.529 by angelzen on Saturday November 27, 2021 @09:31PM (#29365658)
Make that zero. To their credit, the authors of the Bangladesh mask study released the raw data. "The difference between the two groups was small: only 20 cases out of over 340,000 individuals over a span of 8 weeks." Drawing any conclusions from such small amount of data is deeply unserious.

http://www.argmin.net/2021/11/23/mask-rct-revisited

Re:New Concerning Variant: B.1.1.529 by cthalupa on Friday November 26, 2021 @07:50PM (#29355980)
It isn't a political issue to not do studies that require doing things that actively and intentionally put people at things we know are highly likely to put them at risk of physical harm. The world decided this was unethical long before the current political climate.
Re:New Concerning Variant: B.1.1.529 by angelzen on Friday November 26, 2021 @08:53PM (#29356454)
In masks + covid context it feels like "unethical" is used as a thought terminating cliche.

* The pandemic is affecting 8,000,000,000 people all around the world. A large size RCT enrolls X0,000 participants. For example, the Pfizer covid mRNA vaccine clinical trial had 21,728 placebo participants. For every RCT participant, the RCT results are going to inform the course of action for hundreds of thousands of people. This is to say that such RCTs are extremely valuable given the high infectiousness of the virus.

* The risk to the participants is at worst a moderate increase in the chance of being infected with covid. The covid fatality risk to a healthy adult is small. In the US there have been about 50,000 deaths with covid in <50yo age group. An RCT with 20,000 <50yo people on the placebo arm may see about 3 covid deaths assuming all the placebo participants are going to be infected. Realistically, only a fraction of participants are going to actually be infected with covid, thus there is a good chance every single one of the RCT participants will continue their lives just fine, especially if the study designers are careful to not include people with serious comorbidities.

* Vaccines are available to reduce the death risk by another order of magnitude if deemed necessary. Alas, while the vaccines have strong effects in preventing serious covid, they only have a middling effect on preventing infections [edit: after a few months]. The mask/no mask infection effect remains measurable.

* Covid is endemic. Everyone is at risk to to be infected with covid sooner or later. Wearing a mask may decrease the daily risk by a moderate margin, unfortunately integrated over many days the infection probability approaches 1. The RCT is merely speeding the risk by a moderate margin for the placebo arm participants.

* There is a large pool of potential volunteers that don't (want to) wear masks anyways. Adults have the right to volunteer for risky activities, including activities that may result in death.

Re:New Concerning Variant: B.1.1.529 by cthalupa on Saturday November 27, 2021 @09:38AM (#29360478)
This is a well written argument, and I don't disagree with the majority of it. However, there is one key point that I do disagree with, and makes the rest of it moot:

>* There is a large pool of potential volunteers that don't (want to) wear masks anyways. Adults have the right to volunteer for risky activities, including activities that may result in death.

This is certainly true. But the difference is that once we begin performing medical studies that ask this of people, the medical industry is now complicit in adults performing risky activities that may result in death and is asking people to do so, or if doing so, to do so for the benefit of medical research. This is a line that has not been crossed by the modern medical research industry as it has been long decided that this extra pressure, however small, is a lever they do not want to pull because it is fundamentally incompatible with 'Do no harm.'

It isn't 'do no harm, except a little when we think it might outweigh the downsides'

It's a line I don't think we should cross. I understand why someone would disagree with that.

Re:New Concerning Variant: B.1.1.529 by angelzen on Saturday November 27, 2021 @11:23AM (#29361261)
The null hypothesis is the natural state of humanity, without medical intervention.
Re:New Concerning Variant: B.1.1.529 by lern_too_spel on Saturday November 27, 2021 @06:17PM (#29364582)
The hypothesis for why masks work is due to the laboratory-measured reduction in transmission from the host. The only way to test this is to have a large population where most do not wear masks or most do wear masks. You will not find enough volunteer to make such a test possible. Individual mask wearing does not test this hypothesis.
Re:New Concerning Variant: B.1.1.529 by timr on Saturday November 27, 2021 @02:12AM (#29358231)
This is a fantastic comment. Thank you for breaking it down.
Re:New Concerning Variant: B.1.1.529 by GekkePrutser on Friday November 26, 2021 @08:37PM (#29356328)
But what if those people volunteer?
Re:New Concerning Variant: B.1.1.529 by vishho on Saturday November 27, 2021 @03:10AM (#29358490)
I feel like I am going insane. Pure psychopathy or scientism to want randomized controls for studying infection of a deadly virus. Absolutely disgusted. No wonder we had a lab-leak...
Re:New Concerning Variant: B.1.1.529 by cedilla on Friday November 26, 2021 @07:26PM (#29355825)
It is unethical. All your accusations of narrow-mindedness, but you can't see the obvious, glaring ethical problems with such a trial.

Not the least because it would be completely infeasible. You may pretend that we can "simply" do a "controlled experiment" but you ignore how impossible it is to tell any sizeable group of people to behave in a certain way and report honestly about it.

"Randomised control trials" are the platonic ideal but in the real world, you can't endanger people for your curiosity, and you will have greatest problems to actually enforce your test protocol. It's more than "tricky". Unless you have access to some spherical people in a vacuum.

Re:New Concerning Variant: B.1.1.529 by collaborative on Friday November 26, 2021 @07:54PM (#29356001)
You actually want to be exposed to the virus (after vaccination) during the summer and if possible as often as possible after a successful exposure. It's the only way forward. You can't lock it out forever, and you need to play catch up with it as it evolves or by the time you get it your immune system won't know what to do with it
Re:New Concerning Variant: B.1.1.529 by feanaro on Friday November 26, 2021 @06:26PM (#29355362)
Forever? Why would we need to do it forever when we don't do it for any other virus?
Re:New Concerning Variant: B.1.1.529 by codezero on Friday November 26, 2021 @07:17PM (#29355765)
Probably because we should have been, and now some of us have learned. It’s been a pleasure going two years without any upper respiratory illnesses for me. I look forward to being steadfast in that since it’s really not that hard to wear a mask, and it’s not hurting anyone else when I do so.
Re:New Concerning Variant: B.1.1.529 by feanaro on Saturday November 27, 2021 @01:15PM (#29362113)
It's nice not to have upper respiratory illnesses, but I'm not going to be wearing masks forever because of that, especially since it's not clear cut that not ever getting illnesses is a good idea. (Especially since you're bound to get infected at some point. Might as well exercise the immune system a bit.)

Now, I look forward to it being more socially acceptable to wear masks when you have an infection.

Re:New Concerning Variant: B.1.1.529 by ktkoffroth on Friday November 26, 2021 @08:05PM (#29356080)
What happens when you eventually do catch an upper respiratory disease, and your immune system is no longer used to the challenges it presents?
Re:New Concerning Variant: B.1.1.529 by codezero on Friday November 26, 2021 @10:15PM (#29357021)
Are you suggesting that one’s immune system becomes stronger after year over year infection? If so, to what end? Every year? Even when I’m 80? When does my system break down. Isolation seems to solve all of these issues and I hate people so isolation is easy.
Re:New Concerning Variant: B.1.1.529 by feanaro on Saturday November 27, 2021 @01:16PM (#29362122)
> Isolation seems to solve all of these issues and I hate people so isolation is easy.

Ah, so this is the real reason. That's fine, but it's also not really applicable to the wider population and hence isn't about what I originally asked -- which is why we would universally continuing wearing masks forever.

The answer is we wouldn't, because that makes no sense.

Re:New Concerning Variant: B.1.1.529 by codezero on Saturday November 27, 2021 @01:35PM (#29362283)
It has nothing to do with sense and only to do with feelings on all sides. I also mask because I have elderly family and I care that they will die if they get sick at this point, I’m doing my part to minimize the impact on others with what is essentially a zero cost effort. It’s literally the least one can do, next to washing their hands thoroughly, and covering the mouth when coughing or sneezing. That last one is something many people still don’t do, so I’d be happy with a social expectation of fully covering one’s face when expelling saliva and mucus.
Re:New Concerning Variant: B.1.1.529 by codezero on Friday November 26, 2021 @10:02PM (#29356931)
I take advantage of every medical technology available to me. Duh.
Re:New Concerning Variant: B.1.1.529 by spookthesunset on Friday November 26, 2021 @05:48PM (#29355059)
There is no end game to masking. It will be in perpetuity in some places.
Re:New Concerning Variant: B.1.1.529 by bavell on Friday November 26, 2021 @06:01PM (#29355179)
I've never seen anyone in public with an N95 mask since the pandemic started but I've seen plenty of cloth masks, bandanas and those cheap hospital masks.
Re:New Concerning Variant: B.1.1.529 by Aulig on Friday November 26, 2021 @06:18PM (#29355312)
Interesting, in Germany, especially Bavaria, the restrictions have switched to require FFP2 (equivalent to N95 afaik) since quite a while.
Re:New Concerning Variant: B.1.1.529 by stjohnswarts on Friday November 26, 2021 @10:19PM (#29357044)
America loves its theater. We have a whole department of government dedicated to security theater, the TSA
Re:New Concerning Variant: B.1.1.529 by Robotbeat on Friday November 26, 2021 @07:13PM (#29355728)
How can you not have seen any? I see the KN95 type masks all over the place in public and it’s the only kind I use any more, even for my kids.

I live in Virginia, FWIW.

Re:New Concerning Variant: B.1.1.529 by planetsprite on Friday November 26, 2021 @05:40PM (#29354991)
I don't disagree with you on the effectiveness of masks but tuberculosis bacterial cells are far larger than coronavirons.
Re:New Concerning Variant: B.1.1.529 by tenuousemphasis on Friday November 26, 2021 @05:47PM (#29355051)
Coronavirus itself isn't airborne, it travels in aerosolized water droplets, which are significantly larger than coronavirus itself.
Re:New Concerning Variant: B.1.1.529 by wrycoder on Friday November 26, 2021 @07:26PM (#29355824)
But which are in the airbourne size range.